4-amino-2-methylsulfonyl-5-nitro-6-phenylethynylpyrimidine

Base Information

• Chemical Name: 4-amino-2-methylsulfonyl-5-nitro-6-phenylethynylpyrimidine
• CAS No.: 1158949-90-6
• Molecular Formula: C₁₃H₁₀N₄O₄S
• Molecular Weight: 318.313
• Mol file: 1158949-90-6.mol

Synonyms:4-amino-2-methylsulfonyl-5-nitro-6-phenylethynylpyrimidine

Chemical Property of 4-amino-2-methylsulfonyl-5-nitro-6-phenylethynylpyrimidine

Chemical Property:

Purity/Quality:

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Technology Process of 4-amino-2-methylsulfonyl-5-nitro-6-phenylethynylpyrimidine

There total 1 articles about 4-amino-2-methylsulfonyl-5-nitro-6-phenylethynylpyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

4-amino-2-methylthio-5-nitro-6-phenylethynylpyrimidine (949109-51-7) → 4-amino-2-methylsulfonyl-5-nitro-6-phenylethynylpyrimidine (1158949-90-6)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 6h;

DOI:10.1007/s10593-008-0098-1

Reference yield: 85.0%

piperidine (110-89-4) + 4-amino-2-methylsulfonyl-5-nitro-6-phenylethynylpyrimidine (1158949-90-6) → 4-amino-5-nitro-6-[(E)-2-phenyl-2-(1-piperidinyl)ethenyl]-2-piperidinylpyrimidine (1158949-91-7)

Guidance literature:

In dichloromethane; at 20 ℃; for 2h; stereoselective reaction;

DOI:10.1007/s10593-008-0098-1

Reference yield: 80.0%

4-amino-2-methylsulfonyl-5-nitro-6-phenylethynylpyrimidine (1158949-90-6) + aniline (62-53-3) → 4-amino-2-methylsulfonyl-5-nitro-6-[(Z)-2-phenyl-2-(phenylamino)ethenyl]pyrimidine (1158949-93-9)

Guidance literature:

In dichloromethane; at 20 ℃; for 2h; stereoselective reaction;

DOI:10.1007/s10593-008-0098-1

upstream raw materials:

4-amino-2-methylthio-5-nitro-6-phenylethynylpyrimidine

Downstream raw materials:

4-amino-5-nitro-6-[(E)-2-phenyl-2-(1-piperidinyl)ethenyl]-2-piperidinylpyrimidine

4-amino-5-nitro-6-[(Z)-2-phenyl-2-(phenylthio)ethenyl]-2-phenylthiopyrimidine

4-amino-2-methylsulfonyl-5-nitro-6-[(Z)-2-phenyl-2-(phenylamino)ethenyl]pyrimidine