1-Piperidineacetamide, N-(2-((4-chloro-2-(2-chlorobenzoyl)phenyl)methylamino)-2-oxoethyl)-4-(4-chlorophenyl)-4-hydroxy-

Base Information

Chemical Name:1-Piperidineacetamide, N-(2-((4-chloro-2-(2-chlorobenzoyl)phenyl)methylamino)-2-oxoethyl)-4-(4-chlorophenyl)-4-hydroxy-
CAS No.:59180-47-1
Molecular Formula:C₂₉H₂₈Cl₃N₃O₄
Molecular Weight:588.918
Hs Code.:
DSSTox Substance ID:DTXSID60207917
Wikidata:Q83081930
ChEMBL ID:CHEMBL420241

Synonyms:BRN 5202150;1-Piperidineacetamide, N-(2-((4-chloro-2-(2-chlorobenzoyl)phenyl)methylamino)-2-oxoethyl)-4-(4-chlorophenyl)-4-hydroxy-;59180-47-1;C29H28Cl3N3O4;CHEMBL420241;DTXSID60207917;C29-H28-Cl3-N3-O4;LS-113899

Suppliers and Price of 1-Piperidineacetamide, N-(2-((4-chloro-2-(2-chlorobenzoyl)phenyl)methylamino)-2-oxoethyl)-4-(4-chlorophenyl)-4-hydroxy-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-Piperidineacetamide, N-(2-((4-chloro-2-(2-chlorobenzoyl)phenyl)methylamino)-2-oxoethyl)-4-(4-chlorophenyl)-4-hydroxy-

Chemical Property:

Vapor Pressure:1.35E-27mmHg at 25°C
Boiling Point:808.2°C at 760 mmHg
Flash Point:442.6°C
Density:1.378g/cm³
XLogP3:5.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:8
Exact Mass:587.114539
Heavy Atom Count:39
Complexity:861

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CN(C1=C(C=C(C=C1)Cl)C(=O)C2=CC=CC=C2Cl)C(=O)CNC(=O)CN3CCC(CC3)(C4=CC=C(C=C4)Cl)O

Technology Process of 1-Piperidineacetamide, N-(2-((4-chloro-2-(2-chlorobenzoyl)phenyl)methylamino)-2-oxoethyl)-4-(4-chlorophenyl)-4-hydroxy-

There total 2 articles about 1-Piperidineacetamide, N-(2-((4-chloro-2-(2-chlorobenzoyl)phenyl)methylamino)-2-oxoethyl)-4-(4-chlorophenyl)-4-hydroxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 29176-39-4
4-chloro-2-(o-chlorobenzoyl)-N^α-(benzyloxycarbonyl)glycinanilide

: 59180-47-1
N-({[4-Chloro-2-(2-chloro-benzoyl)-phenyl]-methyl-carbamoyl}-methyl)-2-[4-(4-chloro-phenyl)-4-hydroxy-piperidin-1-yl]-acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) NaH / 1.) DMF, oil, 2-5 deg C, 15 min, 2.) DMF, oil, 2-5 deg C, 2 h

2: 97 percent / 20percent HBr / acetic acid / 1 h / Ambient temperature

3: 89 percent / hexamethylphosphoric acid triamide / 5 h

4: 91.5 percent / KI / acetone / 1 h / Heating

5: 84.7 percent / ethanol; CHCl₃; methanol / 3 h / Ambient temperature

With hydrogen bromide; sodium hydride; potassium iodide; In methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; ethanol; chloroform; acetic acid; acetone;
DOI:10.1021/jm00133a006

Reference yield:

: 59180-42-6
4-chloro-2-(o-chlorobenzoyl)-N-methyl-N^α-(chloroacetyl)glycinanilide

: 59180-47-1
N-({[4-Chloro-2-(2-chloro-benzoyl)-phenyl]-methyl-carbamoyl}-methyl)-2-[4-(4-chloro-phenyl)-4-hydroxy-piperidin-1-yl]-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 91.5 percent / KI / acetone / 1 h / Heating

2: 84.7 percent / ethanol; CHCl₃; methanol / 3 h / Ambient temperature

With potassium iodide; In methanol; ethanol; chloroform; acetone;
DOI:10.1021/jm00133a006