(R)-4-((7-bromo-4-(4-methoxyphenylsulfonyl)-1-((1-methyl-1H-imidazol-5-yl)methyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-3-yl)methyl)phenol

Base Information

Chemical Name:(R)-4-((7-bromo-4-(4-methoxyphenylsulfonyl)-1-((1-methyl-1H-imidazol-5-yl)methyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-3-yl)methyl)phenol
CAS No.:1311269-31-4
Molecular Formula:C₂₈H₂₉BrN₄O₄S
Molecular Weight:597.533
Hs Code.:

Synonyms:(R)-4-((7-bromo-4-(4-methoxyphenylsulfonyl)-1-((1-methyl-1H-imidazol-5-yl)methyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-3-yl)methyl)phenol

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Chemical Property of (R)-4-((7-bromo-4-(4-methoxyphenylsulfonyl)-1-((1-methyl-1H-imidazol-5-yl)methyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-3-yl)methyl)phenol

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Technology Process of (R)-4-((7-bromo-4-(4-methoxyphenylsulfonyl)-1-((1-methyl-1H-imidazol-5-yl)methyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-3-yl)methyl)phenol

There total 6 articles about (R)-4-((7-bromo-4-(4-methoxyphenylsulfonyl)-1-((1-methyl-1H-imidazol-5-yl)methyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-3-yl)methyl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1311269-27-8
(R)-4-((7-bromo-4-(4-methoxyphenylsulfonyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-3-yl)methyl)phenol

: 13750-81-7
N-methyl-2-imidazolcarboxaldehyde

: 1311269-31-4
(R)-4-((7-bromo-4-(4-methoxyphenylsulfonyl)-1-((1-methyl-1H-imidazol-5-yl)methyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-3-yl)methyl)phenol

Guidance literature:: (R)-4-((7-bromo-4-(4-methoxyphenylsulfonyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-3-yl)methyl)phenol; N-methyl-2-imidazolcarboxaldehyde; With trifluoroacetic acid; trifluoroacetic anhydride; In toluene; at 20 ℃; for 2h; Inert atmosphere;

With triethylsilane; In toluene; at 20 ℃; for 16h; Inert atmosphere;
DOI:10.1021/jm300624s

Reference yield: 80.0%

: 39021-62-0
1-methylimidazole-5-carbaldehyde

: 1311269-27-8
(R)-4-((7-bromo-4-(4-methoxyphenylsulfonyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-3-yl)methyl)phenol

: 1311269-31-4
(R)-4-((7-bromo-4-(4-methoxyphenylsulfonyl)-1-((1-methyl-1H-imidazol-5-yl)methyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-3-yl)methyl)phenol

Guidance literature:: 1-methylimidazole-5-carbaldehyde; (R)-4-((7-bromo-4-(4-methoxyphenylsulfonyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-3-yl)methyl)phenol; With trifluoroacetic acid; trifluoroacetic anhydride; In toluene; at 20 - 30 ℃; for 2h; Inert atmosphere;

With triethylsilane; In toluene; at 20 ℃; Iknert atmosphere;
DOI:10.1002/anie.201101210

Reference yield:

: 1311269-26-7
(3R)-7-bromo-3-[(4-hydroxyphenyl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-2,5-dione

: 1311269-31-4
(R)-4-((7-bromo-4-(4-methoxyphenylsulfonyl)-1-((1-methyl-1H-imidazol-5-yl)methyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-3-yl)methyl)phenol

Guidance literature:: Multi-step reaction with 3 steps

1.1: borane-THF / tetrahydrofuran / 18 h / Reflux; Inert atmosphere

2.1: pyridine / 0 - 20 °C / Inert atmosphere

3.1: trifluoroacetic acid; trifluoroacetic anhydride / toluene / 2 h / 20 - 30 °C / Inert atmosphere

3.2: 20 °C / Iknert atmosphere

With pyridine; borane-THF; trifluoroacetic acid; trifluoroacetic anhydride; In tetrahydrofuran; toluene;
DOI:10.1002/anie.201101210