(2R)-1-(3,4-methylenedioxyphenyl)-2-(4'-bromo-2'-methoxyphenoxy)propan-1-one

Base Information

Chemical Name:(2R)-1-(3,4-methylenedioxyphenyl)-2-(4'-bromo-2'-methoxyphenoxy)propan-1-one
CAS No.:1426163-30-5
Molecular Formula:C₁₇H₁₅BrO₅
Molecular Weight:379.207
Hs Code.:

Synonyms:(2R)-1-(3,4-methylenedioxyphenyl)-2-(4'-bromo-2'-methoxyphenoxy)propan-1-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R)-1-(3,4-methylenedioxyphenyl)-2-(4'-bromo-2'-methoxyphenoxy)propan-1-one

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Technology Process of (2R)-1-(3,4-methylenedioxyphenyl)-2-(4'-bromo-2'-methoxyphenoxy)propan-1-one

There total 1 articles about (2R)-1-(3,4-methylenedioxyphenyl)-2-(4'-bromo-2'-methoxyphenoxy)propan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1-(3,4-methylenedioxyphenyl)-1-hydroxy-2-(4'-bromo-2'-methoxyphenoxy)propane

: 1426163-30-5
(2R)-1-(3,4-methylenedioxyphenyl)-2-(4'-bromo-2'-methoxyphenoxy)propan-1-one

Guidance literature:: With Dess-Martin periodane; In dichloromethane; for 17h;
DOI:10.1016/j.ejmech.2012.12.013

Reference yield: 84.0%

: 1426163-30-5
(2R)-1-(3,4-methylenedioxyphenyl)-2-(4'-bromo-2'-methoxyphenoxy)propan-1-one

: 1426163-32-7
C₁₇H₁₇BrO₅

Guidance literature:: With sodium tetrahydroborate; 15-crown-5; In methanol; isopropyl alcohol; at -78 ℃; for 48h; Inert atmosphere;
DOI:10.1016/j.ejmech.2012.12.013

Reference yield:

: 1426163-30-5
(2R)-1-(3,4-methylenedioxyphenyl)-2-(4'-bromo-2'-methoxyphenoxy)propan-1-one

: 847476-52-2
C₂₀H₂₂O₅

Guidance literature:: Multi-step reaction with 2 steps

1: 15-crown-5; sodium tetrahydroborate / isopropyl alcohol; methanol / 48 h / -78 °C / Inert atmosphere

2: cesium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 20 h / Inert atmosphere; Reflux

With sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 15-crown-5; cesium fluoride; In tetrahydrofuran; methanol; isopropyl alcohol; 2: |Suzuki Coupling;
DOI:10.1016/j.ejmech.2012.12.013