3,3,3-trifluoro-2-methoxy-2-(3-methoxyphenyl)propionitrile

Base Information

• Chemical Name: 3,3,3-trifluoro-2-methoxy-2-(3-methoxyphenyl)propionitrile
• CAS No.: 324075-44-7
• Molecular Formula: C₁₁H₁₀F₃NO₂
• Molecular Weight: 245.201
• Mol file: 324075-44-7.mol

Synonyms:3,3,3-trifluoro-2-methoxy-2-(3-methoxyphenyl)propionitrile

Chemical Property of 3,3,3-trifluoro-2-methoxy-2-(3-methoxyphenyl)propionitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,3,3-trifluoro-2-methoxy-2-(3-methoxyphenyl)propionitrile

There total 1 articles about 3,3,3-trifluoro-2-methoxy-2-(3-methoxyphenyl)propionitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

2,2,2-trifluoro-1-(3-methoxyphenyl)ethanone (30724-22-2) + dimethyl sulfate (77-78-1) → 3,3,3-trifluoro-2-methoxy-2-(3-methoxyphenyl)propionitrile (324075-44-7)

Guidance literature:

2,2,2-trifluoro-1-(3-methoxyphenyl)ethanone; With sodium cyanide; In 1,2-dimethoxyethane; at 20 ℃; for 0.5h;

dimethyl sulfate; In 1,2-dimethoxyethane; at 60 ℃; for 5h;

DOI:10.1016/S0040-4020(01)00836-5

Reference yield: 61.0%

3,3,3-trifluoro-2-methoxy-2-(3-methoxyphenyl)propionitrile (324075-44-7) → 3,3,3-trifluoro-2-methoxy-2-(3-methoxyphenyl)propylamine (324075-37-8)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 0 - 20 ℃;

DOI:10.1016/S0040-4020(01)00836-5

Reference yield:

3,3,3-trifluoro-2-methoxy-2-(3-methoxyphenyl)propionitrile (324075-44-7) → 6-methoxy-1-styryl-4-(trifluoromethyl)isoquinoline (324075-65-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 61 percent / NaBH₄; CoCl₂ / methanol / 0 - 20 °C

2: 98 percent / ethyl acetate / 2 h / 0 - 20 °C

3: 81 percent / POCl₃ / 16 h / 90 °C

4: 65 percent / acetic anhydride / 16 h / 100 °C

With sodium tetrahydroborate; trichlorophosphate; In methanol; acetic anhydride; ethyl acetate; 3: Pictet-Gams cyclisation;

DOI:10.1016/S0040-4020(01)00836-5

upstream raw materials:

2,2,2-trifluoro-1-(3-methoxyphenyl)ethanone

dimethyl sulfate

Downstream raw materials:

3,3,3-trifluoro-2-methoxy-2-(3-methoxyphenyl)propylamine

N-[2-methoxy-2-(3-methoxyphenyl)-2-(trifluoromethyl)ethyl]acetamide

6-methoxy-1-styryl-4-(trifluoromethyl)isoquinoline

4,6-dimethoxy-1-styryl-4-trifluoromethyl-3,4-dihydroisoquinoline