tert-butyl 4-((2-(2-(trifluoromethoxy)phenyl)acetoyloxy)methyl)thiazol-2-ylcarbamate

Base Information

Chemical Name:tert-butyl 4-((2-(2-(trifluoromethoxy)phenyl)acetoyloxy)methyl)thiazol-2-ylcarbamate
CAS No.:1363397-20-9
Molecular Formula:C₁₈H₁₉F₃N₂O₅S
Molecular Weight:432.42
Hs Code.:

Synonyms:tert-butyl 4-((2-(2-(trifluoromethoxy)phenyl)acetoyloxy)methyl)thiazol-2-ylcarbamate

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Chemical Property of tert-butyl 4-((2-(2-(trifluoromethoxy)phenyl)acetoyloxy)methyl)thiazol-2-ylcarbamate

Chemical Property:

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Technology Process of tert-butyl 4-((2-(2-(trifluoromethoxy)phenyl)acetoyloxy)methyl)thiazol-2-ylcarbamate

There total 2 articles about tert-butyl 4-((2-(2-(trifluoromethoxy)phenyl)acetoyloxy)methyl)thiazol-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 220239-67-8
2-[2-(trifluoromethoxy)phenyl]acetic acid

: 494769-44-7
(4-hydroxymethylthiazol-2-yl)carbamic acid tert-butyl ester

: 1363397-20-9
tert-butyl 4-((2-(2-(trifluoromethoxy)phenyl)acetoyloxy)methyl)thiazol-2-ylcarbamate

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 - 20 ℃; for 8h;
DOI:10.1016/j.ejmech.2012.01.008

Reference yield:

: 189512-01-4
ethyl 2-[(tert-butoxycarbonyl)amino]thiazole-4-carboxylate

: 1363397-20-9
tert-butyl 4-((2-(2-(trifluoromethoxy)phenyl)acetoyloxy)methyl)thiazol-2-ylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: diisobutylaluminium hydride / dichloromethane / 10 h / -78 - 20 °C

1.2: 1 h / 0 - 20 °C

2.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 8 h / 0 - 20 °C

With dmap; diisobutylaluminium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;
DOI:10.1016/j.ejmech.2012.01.008

Reference yield: 85.0%

: 1363397-20-9
tert-butyl 4-((2-(2-(trifluoromethoxy)phenyl)acetoyloxy)methyl)thiazol-2-ylcarbamate

: 1363397-80-1
(2-aminothiazol-4-yl)methyl 2-(2-(trifluoromethoxy)phenyl)acetate

Guidance literature:: tert-butyl 4-((2-(2-(trifluoromethoxy)phenyl)acetoyloxy)methyl)thiazol-2-ylcarbamate; With hydrogenchloride; ethanol; at 0 - 20 ℃; for 4h;

With sodium hydrogencarbonate; In water;
DOI:10.1016/j.ejmech.2012.01.008