2-{3-[4-(4-chlorobenzyl)-5-oxo-[1,4]diazepan-1-yl]-2-hydroxy-propoxy}-N-cyclopropyl-4-fluorobenzamide trifluoroacetate

Base Information

Chemical Name:2-{3-[4-(4-chlorobenzyl)-5-oxo-[1,4]diazepan-1-yl]-2-hydroxy-propoxy}-N-cyclopropyl-4-fluorobenzamide trifluoroacetate
CAS No.:1076242-86-8
Molecular Formula:C₂HF₃O₂*C₂₅H₂₉ClFN₃O₄
Molecular Weight:603.998
Hs Code.:

Synonyms:2-{3-[4-(4-chlorobenzyl)-5-oxo-[1,4]diazepan-1-yl]-2-hydroxy-propoxy}-N-cyclopropyl-4-fluorobenzamide trifluoroacetate

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Chemical Property of 2-{3-[4-(4-chlorobenzyl)-5-oxo-[1,4]diazepan-1-yl]-2-hydroxy-propoxy}-N-cyclopropyl-4-fluorobenzamide trifluoroacetate

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Technology Process of 2-{3-[4-(4-chlorobenzyl)-5-oxo-[1,4]diazepan-1-yl]-2-hydroxy-propoxy}-N-cyclopropyl-4-fluorobenzamide trifluoroacetate

There total 3 articles about 2-{3-[4-(4-chlorobenzyl)-5-oxo-[1,4]diazepan-1-yl]-2-hydroxy-propoxy}-N-cyclopropyl-4-fluorobenzamide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1076243-02-1
4-(4-chlorobenzyl)-[1,4]diazepan-5-one

: 460048-12-8
N-cyclopropyl-4-fluoro-2-[(2S)-oxiran-2-ylmethoxy]benzamide

: 76-05-1
trifluoroacetic acid

: 1076242-86-8
2-{3-[4-(4-chlorobenzyl)-5-oxo-[1,4]diazepan-1-yl]-2-hydroxy-propoxy}-N-cyclopropyl-4-fluorobenzamide trifluoroacetate

Guidance literature:: 4-(4-chlorobenzyl)-[1,4]diazepan-5-one; N-cyclopropyl-4-fluoro-2-[(2S)-oxiran-2-ylmethoxy]benzamide; In ethanol; at 80 ℃; for 5h;

trifluoroacetic acid;

Reference yield:

: 622-95-7
4-chlorobenzyl bromide

: 1076242-86-8
2-{3-[4-(4-chlorobenzyl)-5-oxo-[1,4]diazepan-1-yl]-2-hydroxy-propoxy}-N-cyclopropyl-4-fluorobenzamide trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hexamethylsilazane / tetrahydrofuran / 0.25 h / -70 °C

1.2: 6 h / -75 °C

2.1: trifluoroacetic acid / dichloromethane / 0.83 h / 0 - 20 °C

3.1: ethanol / 5 h / 80 °C

With potassium hexamethylsilazane; trifluoroacetic acid; In tetrahydrofuran; ethanol; dichloromethane;

Reference yield:

: 190900-21-1
5-oxo-[1,4]diazepane-1-carboxylic acid tert-butyl ester

: 1076242-86-8
2-{3-[4-(4-chlorobenzyl)-5-oxo-[1,4]diazepan-1-yl]-2-hydroxy-propoxy}-N-cyclopropyl-4-fluorobenzamide trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hexamethylsilazane / tetrahydrofuran / 0.25 h / -70 °C

1.2: 6 h / -75 °C

2.1: trifluoroacetic acid / dichloromethane / 0.83 h / 0 - 20 °C

3.1: ethanol / 5 h / 80 °C

With potassium hexamethylsilazane; trifluoroacetic acid; In tetrahydrofuran; ethanol; dichloromethane;