(2SR,3S)-3-(Boc-amino)-2-<(4-methoxybenzyl)sulfanyl>-6-oxo(tritylamino)hexanoic acid

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Chemical Name:(2SR,3S)-3-(Boc-amino)-2-<(4-methoxybenzyl)sulfanyl>-6-oxo(tritylamino)hexanoic acid
CAS No.:222409-89-4
Molecular Formula:C₃₈H₄₂N₂O₆S
Molecular Weight:654.827
Hs Code.:

Synonyms:(2SR,3S)-3-(Boc-amino)-2-<(4-methoxybenzyl)sulfanyl>-6-oxo(tritylamino)hexanoic acid

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Chemical Property of (2SR,3S)-3-(Boc-amino)-2-<(4-methoxybenzyl)sulfanyl>-6-oxo(tritylamino)hexanoic acid

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Technology Process of (2SR,3S)-3-(Boc-amino)-2-<(4-methoxybenzyl)sulfanyl>-6-oxo(tritylamino)hexanoic acid

There total 6 articles about (2SR,3S)-3-(Boc-amino)-2-<(4-methoxybenzyl)sulfanyl>-6-oxo(tritylamino)hexanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 222409-82-7
methyl (2S,3S)-3-(Boc-amino)-2-<(4-methoxybenzyl)sulfanyl>-6-oxo(tritylamino)hexanoate

: 222409-89-4
(2SR,3S)-3-(Boc-amino)-2-<(4-methoxybenzyl)sulfanyl>-6-oxo(tritylamino)hexanoic acid

Guidance literature:: With sodium hydroxide; In methanol; water;
DOI:10.1021/jm981066w

Reference yield:

: 132388-69-3,210750-95-1
Boc-L-Gln(Trt)-OH

: 222409-89-4
(2SR,3S)-3-(Boc-amino)-2-<(4-methoxybenzyl)sulfanyl>-6-oxo(tritylamino)hexanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: N-methylmorpholine / tetrahydrofuran / 0.33 h / -20 °C

2: 4.45 g / tetrahydrofuran; diethyl ether / 1 h / Ambient temperature

3: silver benzoate, triethylamine / methanol

4: 1.5 h

5: 1.) lithium diisopropylamide / 1.) THF, heptane, ethylbenzene, -78 deg C, 30 min, 2.) THF, heptane, ethylbenzene, 2 h

6: 95 percent / NaOH / methanol; H₂O

With 4-methyl-morpholine; sodium hydroxide; silver benzoate; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; methanol; diethyl ether; water;
DOI:10.1021/jm981066w

Reference yield:

: C₃₄H₄₀N₂O₇

: 222409-89-4
(2SR,3S)-3-(Boc-amino)-2-<(4-methoxybenzyl)sulfanyl>-6-oxo(tritylamino)hexanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 4.45 g / tetrahydrofuran; diethyl ether / 1 h / Ambient temperature

2: silver benzoate, triethylamine / methanol

3: 1.5 h

4: 1.) lithium diisopropylamide / 1.) THF, heptane, ethylbenzene, -78 deg C, 30 min, 2.) THF, heptane, ethylbenzene, 2 h

5: 95 percent / NaOH / methanol; H₂O

With sodium hydroxide; silver benzoate; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; methanol; diethyl ether; water;
DOI:10.1021/jm981066w