Histrelin

Base Information

• Chemical Name: Histrelin
• CAS No.: 76712-82-8
• Molecular Formula: C66H86 N18 O12
• Molecular Weight: 1323.52
• Hs Code.: 2937190090

Synonyms:ORF 17070;RWJ 17070;Vantas;(Des-Gly10,His(Bzl)6,Pro-NHEt9)-LHRH;Luteinizinghormone-releasing factor (pig),6-[1-(phenylmethyl)-D-histidine]-9-(N-ethyl-L-prolinamide)-10-deglycinamide-;1-9-Luteinizinghormone-releasing factor (swine),6-[1-(phenylmethyl)-D-histidine]-9-(N-ethyl-L-prolinamide)-;

Chemical Property of Histrelin

Chemical Property:

• Appearance/Colour: White or almost white lyophilized powder
• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 1800.6oC at 760 mmHg
• PKA: 9.82±0.15(Predicted)
• Flash Point: 1042.8oC
• PSA: 446.86000
• Density: 1.46 g/cm³
• LogP: 3.79780
• Storage Temp.: −20°C

Purity/Quality:

98% ^*data from raw suppliers

Histrelin 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 60
• Safety Statements: 53-22-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Description: Histrelin, a synthetic gonadotrophin-releasing hormone (GnRH) agonist, was introduced as a first-line therapy for the treatment of central precocious puberty. When administered over a prolonged period, it suppresses the release of gonadotrophin, inhibits ovarian and testicular steroidogenesis, and prevents sexual maturation. Superior to the traditional therapy with progestational agents, histrelin appears to have decelerating effects on skeletal maturation allowing more statural growth and significantly increased final adult height. Histrelin has also been used to treat other disorders including endometriosis, polycystic ovarian disease, uterine leiomyomas, severe premenstrual syndrome and to prevent acute intermittent porphyria.
• Uses: LHRH agonist. [des-Gly10, D-His(Bzl)6]-LH-RH ethylamide has been used:for inducing Batrachoseps gravid females to ovipositfor comparing the effect of LHRH (luteinizing hormone-releasing hormone) agonists and dopamine antagonists in Lithobates pipiensfor inducing oviposition in females of Taricha granulosa and Ensatina eschscoltziito induce spawning in Spea hammondii adults

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