C₁₉H₂₁BrO₄

Base Information

• Chemical Name: C₁₉H₂₁BrO₄
• CAS No.: 1427500-19-3
• Molecular Formula: C₁₉H₂₁BrO₄
• Molecular Weight: 393.277
• Mol file: 1427500-19-3.mol

Synonyms:C₁₉H₂₁BrO₄

Chemical Property of C₁₉H₂₁BrO₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₉H₂₁BrO₄

There total 1 articles about C₁₉H₂₁BrO₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

methyl 4-(3-bromo-2-hydroxyphenyl)butanoate (1427500-17-1) + (R)-2-allyl-4-hydroxycyclopentenone (84986-28-7) → C19H21BrO4 (1427500-19-3)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In toluene; at -10 - -5 ℃; for 4h; Inert atmosphere;

Reference yield:

C19H21BrO4 (1427500-19-3) → C24H30O5

Guidance literature:

Multi-step reaction with 8 steps

1.1: 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride / toluene / 6.5 h / 100 °C / Inert atmosphere

2.1: methanol; sodium tetrahydroborate / 1.5 h / -10 - -5 °C / Inert atmosphere

3.1: dmap / dichloromethane / 1 h / 0 °C / Inert atmosphere

4.1: sodium acetate; palladium dichloride; oxygen / 30 h / 80 °C / 3102.97 - 4654.46 Torr / Molecular sieve

5.1: ozone / dichloromethane; methanol / 0.67 h / -78 - -70 °C / 517.16 Torr

5.2: 0.5 h / -20 - 0 °C / Inert atmosphere

6.1: sodium hydride / 1,2-dimethoxyethane; paraffin oil / 0 °C / Inert atmosphere

6.2: 1.5 h / 0 - 20 °C / Inert atmosphere

7.1: (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; borane-THF / tetrahydrofuran / 1 h / -78 - -70 °C / Inert atmosphere

7.2: -70 - 0 °C / Inert atmosphere

8.1: sodium hydroxide; water / methanol / 3 h / 20 °C

With methanol; dmap; sodium tetrahydroborate; borane-THF; 2,2'-azobis(isobutyronitrile); water; oxygen; tri-n-butyl-tin hydride; sodium acetate; sodium hydride; ozone; sodium hydroxide; palladium dichloride; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; toluene; paraffin oil; 6.1: |Horner-Wadsworth-Emmons Olefination;

upstream raw materials:

methyl 4-(3-bromo-2-hydroxyphenyl)butanoate

(R)-2-allyl-4-hydroxycyclopentenone