2-bromo-4-((2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)methyl)phenyl methanesulfonate

Base Information

Chemical Name:2-bromo-4-((2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)methyl)phenyl methanesulfonate
CAS No.:1435263-59-4
Molecular Formula:C₁₉H₁₉BrN₂O₃S
Molecular Weight:435.341
Hs Code.:

Synonyms:2-bromo-4-((2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)methyl)phenyl methanesulfonate

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Chemical Property of 2-bromo-4-((2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)methyl)phenyl methanesulfonate

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Technology Process of 2-bromo-4-((2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)methyl)phenyl methanesulfonate

There total 3 articles about 2-bromo-4-((2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)methyl)phenyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1435263-48-1
2-bromo-4-(2-oxoethyl)phenyl methanesulfonate

: 343-94-2
tryptamine hydochloride

: 1435263-59-4
2-bromo-4-((2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)methyl)phenyl methanesulfonate

Guidance literature:: In isopropyl alcohol; at 85 ℃; for 24h;
DOI:10.1039/c3ob40661j

Reference yield:

: 1435263-42-5
2-(3-bromo-4-hydroxyphenyl)acetaldehyde

: 1435263-59-4
2-bromo-4-((2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)methyl)phenyl methanesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 0.25 h / 0 - 20 °C / Inert atmosphere

2: isopropyl alcohol / 24 h / 85 °C

With triethylamine; In dichloromethane; isopropyl alcohol; 2: |Pictet-Spengler Synthesis;
DOI:10.1039/c3ob40661j

Reference yield:

: 196081-78-4
3-bromo-4-hydroxyphenylethyl alcohol

: 1435263-59-4
2-bromo-4-((2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)methyl)phenyl methanesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; sulfur trioxide pyridine complex / dimethyl sulfoxide / 1 h / 20 °C

2: triethylamine / dichloromethane / 0.25 h / 0 - 20 °C / Inert atmosphere

3: isopropyl alcohol / 24 h / 85 °C

With sulfur trioxide pyridine complex; triethylamine; In dichloromethane; dimethyl sulfoxide; isopropyl alcohol; 1: |Parikh-Doering Oxidation / 3: |Pictet-Spengler Synthesis;
DOI:10.1039/c3ob40661j