(3R,4R,2'S)-trans-3-methyl-1-(2-hydroxy-2-phenylethyl)-N-phenyl-4-piperidinamine

Base Information

Chemical Name:(3R,4R,2'S)-trans-3-methyl-1-(2-hydroxy-2-phenylethyl)-N-phenyl-4-piperidinamine
CAS No.:166768-15-6
Molecular Formula:C₂₀H₂₆N₂O
Molecular Weight:310.439
Hs Code.:

Synonyms:(3R,4R,2'S)-trans-3-methyl-1-(2-hydroxy-2-phenylethyl)-N-phenyl-4-piperidinamine

Suppliers and Price of (3R,4R,2'S)-trans-3-methyl-1-(2-hydroxy-2-phenylethyl)-N-phenyl-4-piperidinamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3R,4R,2'S)-trans-3-methyl-1-(2-hydroxy-2-phenylethyl)-N-phenyl-4-piperidinamine

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Technology Process of (3R,4R,2'S)-trans-3-methyl-1-(2-hydroxy-2-phenylethyl)-N-phenyl-4-piperidinamine

There total 3 articles about (3R,4R,2'S)-trans-3-methyl-1-(2-hydroxy-2-phenylethyl)-N-phenyl-4-piperidinamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 20780-54-5
(S)-styrene oxide

: 120143-74-0
(3R,4R)-(-)-trans-3-methyl-N-phenyl-4-piperidinamine

: 166768-15-6
(3R,4R,2'S)-trans-3-methyl-1-(2-hydroxy-2-phenylethyl)-N-phenyl-4-piperidinamine

Guidance literature:: at 100 ℃; for 1h;
DOI:10.1021/jm00018a026

Reference yield:

: 58329-00-3
1-benzyl-3-methyl-N-phenyl-4-piperidinamine

: 166768-15-6
(3R,4R,2'S)-trans-3-methyl-1-(2-hydroxy-2-phenylethyl)-N-phenyl-4-piperidinamine

Guidance literature:: Multi-step reaction with 3 steps

1: 8.9 g / H₂ / 10percent Pd/C / ethanol / 6 h / 60 °C / 775.7 Torr

3: 79 percent / 1 h / 100 °C

With hydrogen; palladium on activated charcoal; In ethanol;
DOI:10.1021/jm00018a026