methyl (R,S)-7-[[[4-[N-(benzyloxycarbonyl)-aminoiminomethyl]phenyl]methylamino]carbonyl]-2,3,4,5-tetrahydro-3-oxo-2-(2-phenylethyl)-1H-2-benzazepine-4-acetate

Base Information

Chemical Name:methyl (R,S)-7-[[[4-[N-(benzyloxycarbonyl)-aminoiminomethyl]phenyl]methylamino]carbonyl]-2,3,4,5-tetrahydro-3-oxo-2-(2-phenylethyl)-1H-2-benzazepine-4-acetate
CAS No.:160952-53-4
Molecular Formula:C₃₈H₃₈N₄O₆
Molecular Weight:646.743
Hs Code.:

methyl (R,S)-7-[[[4-[N-(benzyloxycarbonyl)-aminoiminomethyl]phenyl]methylamino]carbonyl]-2,3,4,5-tetrahydro-3-oxo-2-(2-phenylethyl)-1H-2-benzazepine-4-acetate

Synonyms:methyl (R,S)-7-[[[4-[N-(benzyloxycarbonyl)-aminoiminomethyl]phenyl]methylamino]carbonyl]-2,3,4,5-tetrahydro-3-oxo-2-(2-phenylethyl)-1H-2-benzazepine-4-acetate

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Chemical Property of methyl (R,S)-7-[[[4-[N-(benzyloxycarbonyl)-aminoiminomethyl]phenyl]methylamino]carbonyl]-2,3,4,5-tetrahydro-3-oxo-2-(2-phenylethyl)-1H-2-benzazepine-4-acetate

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Technology Process of methyl (R,S)-7-[[[4-[N-(benzyloxycarbonyl)-aminoiminomethyl]phenyl]methylamino]carbonyl]-2,3,4,5-tetrahydro-3-oxo-2-(2-phenylethyl)-1H-2-benzazepine-4-acetate

There total 12 articles about methyl (R,S)-7-[[[4-[N-(benzyloxycarbonyl)-aminoiminomethyl]phenyl]methylamino]carbonyl]-2,3,4,5-tetrahydro-3-oxo-2-(2-phenylethyl)-1H-2-benzazepine-4-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 160952-53-4
methyl (R,S)-7-[[[4-[N-(benzyloxycarbonyl)-aminoiminomethyl]phenyl]methylamino]carbonyl]-2,3,4,5-tetrahydro-3-oxo-2-(2-phenylethyl)-1H-2-benzazepine-4-acetate

Guidance literature:

Reference yield:

: 4--N-methylaniline

: (7-Chlorocarbonyl-3-oxo-2-phenethyl-2,3,4,5-tetrahydro-1H-benzo[c]azepin-4-yl)-acetic acid methyl ester

: 160952-53-4
{7-[(4-{Amino-[(E)-benzyloxycarbonylimino]-methyl}-phenyl)-methyl-carbamoyl]-3-oxo-2-phenethyl-2,3,4,5-tetrahydro-1H-benzo[c]azepin-4-yl}-acetic acid methyl ester

Guidance literature:: With pyridine; In dichloromethane; at 0 - 20 ℃; Yield given;
DOI:10.1016/0040-4039(94)02273-E

Reference yield:

: 7697-26-9
3-bromo-4-methylbenzoic acid

: 160952-53-4
{7-[(4-{Amino-[(E)-benzyloxycarbonylimino]-methyl}-phenyl)-methyl-carbamoyl]-3-oxo-2-phenethyl-2,3,4,5-tetrahydro-1H-benzo[c]azepin-4-yl}-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: 91 percent / 5 mole percent TfOH / diethyl ether / -78 - 20 °C

2: NBS, (PhCO₂)2O / CCl₄ / Heating

3: 49 percent / tetrahydrofuran / Ambient temperature

4: CHCl₃ / Ambient temperature

5: 5 mole percent Pd(OAc)2, 10 mole percent P(o-tol)3, Et₃N / acetonitrile / Heating

6: 10 percent Pd/C, H₂ / methanol / 2585.7 Torr / Ambient temperature

7: 93 percent / TFA / CH₂Cl₂ / 0 - 20 °C

8: 98 percent / Et₃N / toluene / Heating

9: SOCl₂ / Heating

10: pyridine / CH₂Cl₂ / 0 - 20 °C

With pyridine; palladium diacetate; palladium on activated charcoal; N-Bromosuccinimide; thionyl chloride; trifluorormethanesulfonic acid; (PhCO₂)2O; hydrogen; triethylamine; tris-(o-tolyl)phosphine; trifluoroacetic acid; In tetrahydrofuran; methanol; tetrachloromethane; diethyl ether; dichloromethane; chloroform; toluene; acetonitrile;
DOI:10.1016/0040-4039(94)02273-E