5-benzyloxymethyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyuridine 3'-(N,N-diisopropyl)-2-cyanoethyl phosphoramidite

Base Information

Chemical Name:5-benzyloxymethyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyuridine 3'-(N,N-diisopropyl)-2-cyanoethyl phosphoramidite
CAS No.:304849-87-4
Molecular Formula:C₄₇H₅₅N₄O₉P
Molecular Weight:850.949
Hs Code.:

Synonyms:5-benzyloxymethyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyuridine 3'-(N,N-diisopropyl)-2-cyanoethyl phosphoramidite

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Chemical Property of 5-benzyloxymethyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyuridine 3'-(N,N-diisopropyl)-2-cyanoethyl phosphoramidite

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Technology Process of 5-benzyloxymethyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyuridine 3'-(N,N-diisopropyl)-2-cyanoethyl phosphoramidite

There total 13 articles about 5-benzyloxymethyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyuridine 3'-(N,N-diisopropyl)-2-cyanoethyl phosphoramidite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 124482-92-4,89992-70-1
2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

: 304849-85-2
5-[(benzyloxy)methyl]-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)uridine

: 304849-87-4
5-benzyloxymethyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyuridine 3'-(N,N-diisopropyl)-2-cyanoethyl phosphoramidite

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 1h;
DOI:10.1002/1522-2675(20000809)83:8<1962::AID-HLCA1962>3.0.CO;2-8

Reference yield:

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 304849-87-4
5-benzyloxymethyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyuridine 3'-(N,N-diisopropyl)-2-cyanoethyl phosphoramidite

Guidance literature:: Multi-step reaction with 2 steps

1: 62 percent / pyridine / 2 h / 20 °C

2: 76 percent / iPr₂NEt / CH₂Cl₂ / 2 h

With pyridine; N-ethyl-N,N-diisopropylamine; In dichloromethane;

Reference yield:

: 19083-35-3
5-(benzyloxy)methyl-2′-deoxyuridine

: 304849-87-4
5-benzyloxymethyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyuridine 3'-(N,N-diisopropyl)-2-cyanoethyl phosphoramidite

Guidance literature:: Multi-step reaction with 2 steps

1: 62 percent / pyridine / 2 h / 20 °C

2: 76 percent / iPr₂NEt / CH₂Cl₂ / 2 h

With pyridine; N-ethyl-N,N-diisopropylamine; In dichloromethane;