3'-dephenyl-3'-(2,2-difluoroethenyl)-2-debenzoyl-2-(3-methoxybenzoyl)-10-dimethylcarbamoyldocetaxel

Base Information

Chemical Name:3'-dephenyl-3'-(2,2-difluoroethenyl)-2-debenzoyl-2-(3-methoxybenzoyl)-10-dimethylcarbamoyldocetaxel
CAS No.:926306-92-5
Molecular Formula:C₄₃H₅₆F₂N₂O₁₆
Molecular Weight:894.918
Hs Code.:

Synonyms:3'-dephenyl-3'-(2,2-difluoroethenyl)-2-debenzoyl-2-(3-methoxybenzoyl)-10-dimethylcarbamoyldocetaxel

Suppliers and Price of 3'-dephenyl-3'-(2,2-difluoroethenyl)-2-debenzoyl-2-(3-methoxybenzoyl)-10-dimethylcarbamoyldocetaxel

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3'-dephenyl-3'-(2,2-difluoroethenyl)-2-debenzoyl-2-(3-methoxybenzoyl)-10-dimethylcarbamoyldocetaxel

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3'-dephenyl-3'-(2,2-difluoroethenyl)-2-debenzoyl-2-(3-methoxybenzoyl)-10-dimethylcarbamoyldocetaxel

There total 10 articles about 3'-dephenyl-3'-(2,2-difluoroethenyl)-2-debenzoyl-2-(3-methoxybenzoyl)-10-dimethylcarbamoyldocetaxel which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₅₈H₉₀F₂N₂O₁₆Si₂

: 926306-92-5
3'-dephenyl-3'-(2,2-difluoroethenyl)-2-debenzoyl-2-(3-methoxybenzoyl)-10-dimethylcarbamoyldocetaxel

Guidance literature:: With pyridine; hydrogen fluoride; In acetonitrile; at 0 - 20 ℃;
DOI:10.1016/j.jfluchem.2012.07.007

Reference yield:

: 194720-19-9
7,10,13-tris(triethylsilyl)-10-deacetylbaccatin III

: 926306-92-5
3'-dephenyl-3'-(2,2-difluoroethenyl)-2-debenzoyl-2-(3-methoxybenzoyl)-10-dimethylcarbamoyldocetaxel

Guidance literature:: Multi-step reaction with 7 steps

1: sodium bis(2-methoxyethoxy)aluminium dihydride / tetrahydrofuran / -10 °C

2: diisopropyl-carbodiimide; dmap / dichloromethane

3: pyridine; hydrogen fluoride / acetonitrile

4: 1H-imidazole / N,N-dimethyl-formamide / 2 h / 20 °C

5: lithium hexamethyldisilazane / tetrahydrofuran

6: lithium hexamethyldisilazane / tetrahydrofuran / -40 °C

7: pyridine; hydrogen fluoride / acetonitrile / 0 - 20 °C

With pyridine; 1H-imidazole; dmap; hydrogen fluoride; sodium bis(2-methoxyethoxy)aluminium dihydride; lithium hexamethyldisilazane; diisopropyl-carbodiimide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.jfluchem.2012.07.007

Reference yield:

: 259522-65-1
7,10,13-tri(triethylsilyl)-2-debenzoyl-2-(3-methoxybenzoyl)-10-deacetylbaccatin III

: 926306-92-5
3'-dephenyl-3'-(2,2-difluoroethenyl)-2-debenzoyl-2-(3-methoxybenzoyl)-10-dimethylcarbamoyldocetaxel

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine; hydrogen fluoride / acetonitrile

2: 1H-imidazole / N,N-dimethyl-formamide / 2 h / 20 °C

3: lithium hexamethyldisilazane / tetrahydrofuran

4: lithium hexamethyldisilazane / tetrahydrofuran / -40 °C

5: pyridine; hydrogen fluoride / acetonitrile / 0 - 20 °C

With pyridine; 1H-imidazole; hydrogen fluoride; lithium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.jfluchem.2012.07.007