C₁₉H₁₅F₃N₄O

Base Information

Chemical Name:C₁₉H₁₅F₃N₄O
CAS No.:1160501-79-0
Molecular Formula:C₁₉H₁₅F₃N₄O
Molecular Weight:372.35
Hs Code.:

C<sub>19</sub>H<sub>15</sub>F<sub>3</sub>N<sub>4</sub>O

Synonyms:C₁₉H₁₅F₃N₄O

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Chemical Property of C₁₉H₁₅F₃N₄O

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Technology Process of C₁₉H₁₅F₃N₄O

There total 14 articles about C₁₉H₁₅F₃N₄O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1620328-45-1
C₃₈H₂₉F₃N₄O

: 1160501-79-0
C₁₉H₁₅F₃N₄O

Guidance literature:: With N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid; trifluoroacetic acid; In dichloromethane; at 0 ℃; for 2h;
DOI:10.1016/j.bmcl.2014.05.082

Reference yield:

: 1620328-25-7
C₄₀H₃₁F₃N₄O₂

: 1160501-79-0
C₁₉H₁₅F₃N₄O

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / tetrahydrofuran; methanol / 1 h / 0 °C

2: N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid; trifluoroacetic acid / dichloromethane / 2 h / 0 °C

With N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/j.bmcl.2014.05.082

Reference yield:

: 1160502-31-7
4-iodo-3-(trifluoromethyl)-1-tritylpyrazolo[5,4-b]pyridine

: 1160501-79-0
C₁₉H₁₅F₃N₄O

Guidance literature:: Multi-step reaction with 4 steps

1.1: palladium diacetate; 1,4-di(diphenylphosphino)-butane; tert-butylamine; propyl cyanide / water / 16 h / 120 °C

2.1: bis(tri-t-butylphosphine)palladium⁽⁰⁾; N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 0.5 h / 130 °C / Microwave irradiation

2.2: 5 h / 20 °C / 760.05 Torr

3.1: sodium hydroxide / tetrahydrofuran; methanol / 1 h / 0 °C

4.1: N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid; trifluoroacetic acid / dichloromethane / 2 h / 0 °C

With propyl cyanide; bis(tri-t-butylphosphine)palladium⁽⁰⁾; N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid; palladium diacetate; tert-butylamine; N-ethyl-N,N-diisopropylamine; 1,4-di(diphenylphosphino)-butane; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; 1.1: |Suzuki Coupling / 2.1: |Heck Reaction;
DOI:10.1016/j.bmcl.2014.05.082