2-{[(R)-2-(2-tert-butyldiphenylsilyloxy)-1-phenylethylamino]methyl}phenylamine

Base Information

Chemical Name:2-{[(R)-2-(2-tert-butyldiphenylsilyloxy)-1-phenylethylamino]methyl}phenylamine
CAS No.:855307-24-3
Molecular Formula:C₃₁H₃₆N₂OSi
Molecular Weight:480.725
Hs Code.:

Synonyms:2-{[(R)-2-(2-tert-butyldiphenylsilyloxy)-1-phenylethylamino]methyl}phenylamine

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Chemical Property of 2-{[(R)-2-(2-tert-butyldiphenylsilyloxy)-1-phenylethylamino]methyl}phenylamine

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Technology Process of 2-{[(R)-2-(2-tert-butyldiphenylsilyloxy)-1-phenylethylamino]methyl}phenylamine

There total 4 articles about 2-{[(R)-2-(2-tert-butyldiphenylsilyloxy)-1-phenylethylamino]methyl}phenylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 855307-23-2
(R)-2-(2-aminobenzylamino)-2-phenylethanol

: 58479-61-1
tert-butylchlorodiphenylsilane

: 855307-24-3
2-{[(R)-2-(2-tert-butyldiphenylsilyloxy)-1-phenylethylamino]methyl}phenylamine

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 18h;
DOI:10.1002/ejoc.200400682

Reference yield:

: (R)-2-{[1-(2-Nitro-phenyl)-meth-(E)-ylidene]-amino}-2-phenyl-ethanol

: 855307-24-3
2-{[(R)-2-(2-tert-butyldiphenylsilyloxy)-1-phenylethylamino]methyl}phenylamine

Guidance literature:: Multi-step reaction with 3 steps

1: 8.2 g / NaBH₄ / methanol / 20 °C

2: 83 percent / hydrogen / Pd/C / ethanol / 18 h / 20 °C / 760 Torr

3: 72 percent / imidazole / dimethylformamide / 18 h / 20 °C

With 1H-imidazole; sodium tetrahydroborate; hydrogen; palladium on activated charcoal; In methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1002/ejoc.200400682

Reference yield:

: 855307-22-1
(R)-2-(2-nitrobenzylamino)-2-phenylethanol

: 855307-24-3
2-{[(R)-2-(2-tert-butyldiphenylsilyloxy)-1-phenylethylamino]methyl}phenylamine

Guidance literature:: Multi-step reaction with 2 steps

1: 83 percent / hydrogen / Pd/C / ethanol / 18 h / 20 °C / 760 Torr

2: 72 percent / imidazole / dimethylformamide / 18 h / 20 °C

With 1H-imidazole; hydrogen; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1002/ejoc.200400682