ethyl 4-(4-fluorophenyl)-6-methyl-2-oxo-3,4-dihydro-2H-pyran-5-carboxylate

Base Information

• Chemical Name: ethyl 4-(4-fluorophenyl)-6-methyl-2-oxo-3,4-dihydro-2H-pyran-5-carboxylate
• CAS No.: 1261120-06-2
• Molecular Formula: C₁₅H₁₅FO₄
• Molecular Weight: 278.28
• Mol file: 1261120-06-2.mol

Synonyms:ethyl 4-(4-fluorophenyl)-6-methyl-2-oxo-3,4-dihydro-2H-pyran-5-carboxylate

Chemical Property of ethyl 4-(4-fluorophenyl)-6-methyl-2-oxo-3,4-dihydro-2H-pyran-5-carboxylate

Chemical Property:

Purity/Quality:

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Technology Process of ethyl 4-(4-fluorophenyl)-6-methyl-2-oxo-3,4-dihydro-2H-pyran-5-carboxylate

There total 2 articles about ethyl 4-(4-fluorophenyl)-6-methyl-2-oxo-3,4-dihydro-2H-pyran-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

3-(4-fluoro-phenyl)-propenal (51791-26-5,24654-55-5,213617-57-3) + ethyl acetoacetate (141-97-9) → ethyl 4-(4-fluorophenyl)-6-methyl-2-oxo-3,4-dihydro-2H-pyran-5-carboxylate (1261120-06-2)

Guidance literature:

With 2-mesityl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-2-ium tetrafluoroborate; 1,4-diaza-bicyclo[2.2.2]octane; hexachloroethane; caesium carbonate; In tetrahydrofuran; tert-butyl alcohol; at 20 ℃; for 12h; Schlenk technique; Molecular sieve; Inert atmosphere;

DOI:10.1002/anie.201611692

Reference yield: 58.0%

ethyl acetoacetate (141-97-9) + 3-(4-fluorophenyl)-2-propynal (74929-23-0) → ethyl 4-(4-fluorophenyl)-6-methyl-2-oxo-3,4-dihydro-2H-pyran-5-carboxylate (1261120-06-2)

Guidance literature:

With potassium tert-butylate; 1,3-bis(mesityl)imidazolium chloride; In tetrahydrofuran; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1002/adsc.201000240

upstream raw materials:

ethyl acetoacetate

3-(4-fluorophenyl)-2-propynal

3-(4-fluoro-phenyl)-propenal