4-[2-(5,6,7,8-tetrahydro[1,8]naphthyridin-2-yl)ethyl]benzoic acid ethyl ester

Base Information

Chemical Name:4-[2-(5,6,7,8-tetrahydro[1,8]naphthyridin-2-yl)ethyl]benzoic acid ethyl ester
CAS No.:174666-12-7
Molecular Formula:C₁₉H₂₂N₂O₂
Molecular Weight:310.396
Hs Code.:

Synonyms:4-[2-(5,6,7,8-tetrahydro[1,8]naphthyridin-2-yl)ethyl]benzoic acid ethyl ester

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Chemical Property of 4-[2-(5,6,7,8-tetrahydro[1,8]naphthyridin-2-yl)ethyl]benzoic acid ethyl ester

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Technology Process of 4-[2-(5,6,7,8-tetrahydro[1,8]naphthyridin-2-yl)ethyl]benzoic acid ethyl ester

There total 4 articles about 4-[2-(5,6,7,8-tetrahydro[1,8]naphthyridin-2-yl)ethyl]benzoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 174666-11-6
4-(2-[1,8]naphthyridin-2-ylethyl)benzoic acid ethyl ester

: 174666-12-7
4-[2-(5,6,7,8-tetrahydro[1,8]naphthyridin-2-yl)ethyl]benzoic acid ethyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; for 18h; under 760 Torr;
DOI:10.1021/jm000133v

Reference yield:

: 7521-41-7
2-Aminonicotinaldehyde

: 174666-12-7
4-[2-(5,6,7,8-tetrahydro[1,8]naphthyridin-2-yl)ethyl]benzoic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 60 percent / L-proline / ethanol / 18 h / Heating

2: 52 percent / H₂ / 10 percent Pd/C / ethanol / 18 h / 760 Torr

With hydrogen; L-proline; palladium on activated charcoal; In ethanol; 1: Condensation / 2: Catalytic hydrogenation;
DOI:10.1021/jm000133v

Reference yield:

: 51934-41-9
4-iodobenzoic acid ethyl ester

: 174666-12-7
4-[2-(5,6,7,8-tetrahydro[1,8]naphthyridin-2-yl)ethyl]benzoic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / NEt₃; Pd(OAc)2 / acetonitrile / 16 h / 60 °C

2: 60 percent / L-proline / ethanol / 18 h / Heating

3: 52 percent / H₂ / 10 percent Pd/C / ethanol / 18 h / 760 Torr

With palladium diacetate; hydrogen; triethylamine; L-proline; palladium on activated charcoal; In ethanol; acetonitrile; 1: Substitution / 2: Condensation / 3: Catalytic hydrogenation;
DOI:10.1021/jm000133v