(R)-1-(3-morpholinopropyl)-8-(1-phenylethylamino)oxazolo[4,5-g]quinazolin-2(1H)-one

Base Information

Chemical Name:(R)-1-(3-morpholinopropyl)-8-(1-phenylethylamino)oxazolo[4,5-g]quinazolin-2(1H)-one
CAS No.:1393835-28-3
Molecular Formula:C₂₄H₂₇N₅O₃
Molecular Weight:433.51
Hs Code.:

Synonyms:(R)-1-(3-morpholinopropyl)-8-(1-phenylethylamino)oxazolo[4,5-g]quinazolin-2(1H)-one

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Chemical Property of (R)-1-(3-morpholinopropyl)-8-(1-phenylethylamino)oxazolo[4,5-g]quinazolin-2(1H)-one

Chemical Property:

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Technology Process of (R)-1-(3-morpholinopropyl)-8-(1-phenylethylamino)oxazolo[4,5-g]quinazolin-2(1H)-one

There total 7 articles about (R)-1-(3-morpholinopropyl)-8-(1-phenylethylamino)oxazolo[4,5-g]quinazolin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1393835-75-0
8-chloro-1-(3-morpholinopropyl)oxazolo[4,5-g]quinazolin-2(1H)-one

: 3886-69-9
(R)-1-phenyl-ethyl-amine

: 1393835-28-3
(R)-1-(3-morpholinopropyl)-8-(1-phenylethylamino)oxazolo[4,5-g]quinazolin-2(1H)-one

Guidance literature:: With triethylamine; In isopropyl alcohol; Reflux;
DOI:10.1016/j.ejmech.2012.06.055

Reference yield:

: 139284-98-3
ethyl 2-oxo-2,3-dihydrobenzo[d]oxazole-5-carboxylate

: 1393835-28-3
(R)-1-(3-morpholinopropyl)-8-(1-phenylethylamino)oxazolo[4,5-g]quinazolin-2(1H)-one

Guidance literature:: Multi-step reaction with 6 steps

1: nitric acid / 8 h / 0 - 60 °C

2: iron; acetic acid / methanol / 65 °C

3: potassium carbonate; potassium iodide / acetonitrile / 3 h / 70 °C

4: ethanol / 24 h / Inert atmosphere; Reflux

5: thionyl chloride / N,N-dimethyl-formamide / 16 h / Reflux

6: triethylamine / isopropyl alcohol / Reflux

With thionyl chloride; nitric acid; iron; potassium carbonate; acetic acid; triethylamine; potassium iodide; In methanol; ethanol; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;
DOI:10.1016/j.ejmech.2012.06.055

Reference yield:

: 1393835-74-9
ethyl 6-amino-2-oxo-2,3-dihydrobenzo[d]oxazole-5-carboxylate

: 1393835-28-3
(R)-1-(3-morpholinopropyl)-8-(1-phenylethylamino)oxazolo[4,5-g]quinazolin-2(1H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate; potassium iodide / acetonitrile / 3 h / 70 °C

2: ethanol / 24 h / Inert atmosphere; Reflux

3: thionyl chloride / N,N-dimethyl-formamide / 16 h / Reflux

4: triethylamine / isopropyl alcohol / Reflux

With thionyl chloride; potassium carbonate; triethylamine; potassium iodide; In ethanol; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;
DOI:10.1016/j.ejmech.2012.06.055