1-(3-(1-(7H-pyrrolo[2,3-d]pyrimidine-4-yl)-1H-indole-6-yl)phenyl)-3-(2-methoxyphenyl)urea

Base Information

Chemical Name:1-(3-(1-(7H-pyrrolo[2,3-d]pyrimidine-4-yl)-1H-indole-6-yl)phenyl)-3-(2-methoxyphenyl)urea
CAS No.:1298084-29-3
Molecular Formula:C₂₈H₂₂N₆O₂
Molecular Weight:474.522
Hs Code.:

Synonyms:1-(3-(1-(7H-pyrrolo[2,3-d]pyrimidine-4-yl)-1H-indole-6-yl)phenyl)-3-(2-methoxyphenyl)urea

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Chemical Property of 1-(3-(1-(7H-pyrrolo[2,3-d]pyrimidine-4-yl)-1H-indole-6-yl)phenyl)-3-(2-methoxyphenyl)urea

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Technology Process of 1-(3-(1-(7H-pyrrolo[2,3-d]pyrimidine-4-yl)-1H-indole-6-yl)phenyl)-3-(2-methoxyphenyl)urea

There total 8 articles about 1-(3-(1-(7H-pyrrolo[2,3-d]pyrimidine-4-yl)-1H-indole-6-yl)phenyl)-3-(2-methoxyphenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1298084-47-5
(4-(6-(3-aminophenyl)-1H-indole-1-yl)-7H-pyrrolo[2,3-d]pyrimidine-7-yl)methyl pivalate

: 700-87-8
1-Isocyanato-2-methoxy-benzene

: 1298084-29-3
1-(3-(1-(7H-pyrrolo[2,3-d]pyrimidine-4-yl)-1H-indole-6-yl)phenyl)-3-(2-methoxyphenyl)urea

Guidance literature:: (4-(6-(3-aminophenyl)-1H-indole-1-yl)-7H-pyrrolo[2,3-d]pyrimidine-7-yl)methyl pivalate; 1-Isocyanato-2-methoxy-benzene; In tetrahydrofuran; at 20 - 50 ℃; for 3h;

With water; sodium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 2h;

Reference yield:

: C₃₄H₃₂N₆O₄

: 1298084-29-3
1-(3-(1-(7H-pyrrolo[2,3-d]pyrimidine-4-yl)-1H-indole-6-yl)phenyl)-3-(2-methoxyphenyl)urea

Guidance literature:: With water; sodium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 2h;

Reference yield:

: 3680-69-1
4-chloro-1H-pyrrolo[2,3-d]pyrimidine

: 1298084-29-3
1-(3-(1-(7H-pyrrolo[2,3-d]pyrimidine-4-yl)-1H-indole-6-yl)phenyl)-3-(2-methoxyphenyl)urea

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 0 °C

1.2: 1.5 h / 0 - 20 °C

2.1: caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / palladium diacetate / 1,4-dioxane / 2 h / 120 °C / In a sealed reactor

3.1: tin(II) chloride dihdyrate / ethanol / 1.5 h / 80 °C

4.1: tetrahydrofuran / 3 h / 20 - 50 °C

4.2: 2 h / 20 °C

With tin(II) chloride dihdyrate; sodium hydride; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; ethanol; mineral oil;