naphthalene-2-sulfonic acid [1-(3-cyanobenzyl)-2-oxopiperidin-3-(S)-yl]amide

Base Information

Chemical Name:naphthalene-2-sulfonic acid [1-(3-cyanobenzyl)-2-oxopiperidin-3-(S)-yl]amide
CAS No.:186550-61-8
Molecular Formula:C₂₃H₂₁N₃O₃S
Molecular Weight:419.504
Hs Code.:

Synonyms:naphthalene-2-sulfonic acid [1-(3-cyanobenzyl)-2-oxopiperidin-3-(S)-yl]amide

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Chemical Property of naphthalene-2-sulfonic acid [1-(3-cyanobenzyl)-2-oxopiperidin-3-(S)-yl]amide

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Technology Process of naphthalene-2-sulfonic acid [1-(3-cyanobenzyl)-2-oxopiperidin-3-(S)-yl]amide

There total 5 articles about naphthalene-2-sulfonic acid [1-(3-cyanobenzyl)-2-oxopiperidin-3-(S)-yl]amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24964-64-5
3-Cyanobenzaldehyde

: 186550-61-8
naphthalene-2-sulfonic acid [1-(3-cyanobenzyl)-2-oxopiperidin-3-(S)-yl]amide

Guidance literature:: Multi-step reaction with 4 steps

1: ZnCl₂; sodium cyanoborohydride / methanol / 16 h / 20 °C

2: 0.26 g / BOP; KHCO₃ / dimethylformamide / 16 h

3: CH₂Cl₂ / 3 h / 20 °C

4: Et₃N / CH₂Cl₂ / 2 h

With sodium cyanoborohydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; potassium hydrogencarbonate; triethylamine; zinc(II) chloride; In methanol; dichloromethane; N,N-dimethyl-formamide; 1: reductive N-alkylation / 2: Cyclization / 3: acidolysis / 4: Condensation;
DOI:10.1021/jm990040h

Reference yield:

: 21887-64-9
N₂-(tert-butoxycarbonyl)-L-ornithine

: 186550-61-8
naphthalene-2-sulfonic acid [1-(3-cyanobenzyl)-2-oxopiperidin-3-(S)-yl]amide

Guidance literature:: Multi-step reaction with 4 steps

1: ZnCl₂; sodium cyanoborohydride / methanol / 16 h / 20 °C

2: 0.26 g / BOP; KHCO₃ / dimethylformamide / 16 h

3: CH₂Cl₂ / 3 h / 20 °C

4: Et₃N / CH₂Cl₂ / 2 h

With sodium cyanoborohydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; potassium hydrogencarbonate; triethylamine; zinc(II) chloride; In methanol; dichloromethane; N,N-dimethyl-formamide; 1: reductive N-alkylation / 2: Cyclization / 3: acidolysis / 4: Condensation;
DOI:10.1021/jm990040h

Reference yield:

: 186550-60-7
[1-(3-cyanobenzyl)-2-oxopiperidin-3-(S)-yl]carbamic acid tert butyl ester

: 186550-61-8
naphthalene-2-sulfonic acid [1-(3-cyanobenzyl)-2-oxopiperidin-3-(S)-yl]amide

Guidance literature:: Multi-step reaction with 2 steps

1: CH₂Cl₂ / 3 h / 20 °C

2: Et₃N / CH₂Cl₂ / 2 h

With triethylamine; In dichloromethane; 1: acidolysis / 2: Condensation;
DOI:10.1021/jm990040h