2-[(Methylamino)methyl]-alpha-phenylbenzenemethanol

Base Information

• Chemical Name: 2-[(Methylamino)methyl]-alpha-phenylbenzenemethanol
• CAS No.: 15496-39-6
• Molecular Formula: C₁₅H₁₇NO
• Molecular Weight: 227.306
• DSSTox Substance ID: DTXSID501242779
• Mol file: 15496-39-6.mol

Synonyms:2-[(Methylamino)methyl]-alpha-phenylbenzenemethanol;DTXSID501242779;15496-39-6

Chemical Property of 2-[(Methylamino)methyl]-alpha-phenylbenzenemethanol

Chemical Property:

• XLogP3: 2.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 227.131014166
• Heavy Atom Count: 17
• Complexity: 213

Purity/Quality:

95%+ or 98%+ ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CNCC1=CC=CC=C1C(C2=CC=CC=C2)O

Technology Process of 2-[(Methylamino)methyl]-alpha-phenylbenzenemethanol

There total 2 articles about 2-[(Methylamino)methyl]-alpha-phenylbenzenemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

C16H14F3NO3S → [2-(methylamino-methyl)-phenyl]-phenyl-methanol (15496-39-6)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 12h; Inert atmosphere; Sealed tube; Reflux;

DOI:10.1002/adsc.201200889

Reference yield:

→ [2-(methylamino-methyl)-phenyl]-phenyl-methanol (15496-39-6)

Guidance literature:

entspr. Dilithioamin 2, Benzaldehyd (Tab. II);

DOI:10.1021/jo00811a008

Reference yield:

[2-(methylamino-methyl)-phenyl]-phenyl-methanol (15496-39-6) → 4-methyl-1-phenyl-4,5-dihydro-1H-benzo[e][1,3]thiazepin-3-ylideneamine

Guidance literature:

Multi-step reaction with 2 steps

1: (i), (ii) ClCO₂Et, (iii) NH₃

2: HCl / ethanol; acetic acid / 5 h

With hydrogenchloride; In ethanol; acetic acid;

DOI:10.1002/hlca.19770600840

Downstream raw materials:

1-[2-(hydroxy-phenyl-methyl)-benzyl]-1-methyl-thiourea

4-methyl-1-phenyl-4,5-dihydro-1H-benzo[e][1,3]oxazepin-3-one