(S)-1-((2S,3S,4R)-3-hydroxy-2-hydroxymethyl-4-methyl-5-oxo-pyrrolidin-2-yl)-2-methyl-propyl benzoate

Base Information

Chemical Name:(S)-1-((2S,3S,4R)-3-hydroxy-2-hydroxymethyl-4-methyl-5-oxo-pyrrolidin-2-yl)-2-methyl-propyl benzoate
CAS No.:876952-13-5
Molecular Formula:C₁₇H₂₃NO₅
Molecular Weight:321.373
Hs Code.:

Synonyms:(S)-1-((2S,3S,4R)-3-hydroxy-2-hydroxymethyl-4-methyl-5-oxo-pyrrolidin-2-yl)-2-methyl-propyl benzoate

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Chemical Property of (S)-1-((2S,3S,4R)-3-hydroxy-2-hydroxymethyl-4-methyl-5-oxo-pyrrolidin-2-yl)-2-methyl-propyl benzoate

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Technology Process of (S)-1-((2S,3S,4R)-3-hydroxy-2-hydroxymethyl-4-methyl-5-oxo-pyrrolidin-2-yl)-2-methyl-propyl benzoate

There total 13 articles about (S)-1-((2S,3S,4R)-3-hydroxy-2-hydroxymethyl-4-methyl-5-oxo-pyrrolidin-2-yl)-2-methyl-propyl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 876950-20-8
(3R,4S,5S,6S,8R)-4-hydroxy-6-isopropyl-3-methyl-8-phenyl-7,9-dioxa-1-azaspiro[4.5]decan-2-one

: 876952-13-5
(S)-1-((2S,3S,4R)-3-hydroxy-2-hydroxymethyl-4-methyl-5-oxo-pyrrolidin-2-yl)-2-methyl-propyl benzoate

Guidance literature:: With 3,3-dimethyldioxirane; In acetone; at 0 - 3 ℃; for 18h;
DOI:10.1039/b516311k

Reference yield:

: 1125-88-8
benzaldehyde dimethyl acetal

: 876952-13-5
(S)-1-((2S,3S,4R)-3-hydroxy-2-hydroxymethyl-4-methyl-5-oxo-pyrrolidin-2-yl)-2-methyl-propyl benzoate

Guidance literature:: Multi-step reaction with 12 steps

1: 78 percent / PPTS / benzene / Heating

2: 100 percent / H₂ / Lindlar catalyst / methanol / 20 °C

3: MnO₂; 4 Angstroem molecular sieves / CH₂Cl₂ / Heating

4: NaCNBH₃; AcOH / methanol / 0 °C

5: 83 percent / KHMDS / tetrahydrofuran; toluene / 6 h / -30 °C

6: 93 percent / TPAP; 4-Angstroem molecular sieves; NMO / acetonitrile

7: aq. NaClO₂; NaH₂PO₄; 2-methyl-2-butene / 2-methyl-propan-2-ol / 0 °C

8: NaBH₄ / methanol / 20 °C

9: 96 percent / K₂OsO₂(OH)4; aq. citric acid; NMO / 2-methyl-propan-2-ol / 20 °C

10: 100 percent / tetrahydrofuran / Heating

11: n-Bu₃SnH; AIBN / toluene / Heating

12: 90 percent / dimethyldioxirane / acetone / 18 h / 0 - 3 °C

With manganese(IV) oxide; sodium chlorite; sodium tetrahydroborate; sodium dihydrogenphosphate; N-methyl-2-indolinone; tetrapropylammonium perruthennate; 2-methyl-but-2-ene; potassium dioxotetrahydroxoosmate(VI); 2,2'-azobis(isobutyronitrile); 4 A molecular sieve; hydrogen; tri-n-butyl-tin hydride; 3,3-dimethyldioxirane; pyridinium p-toluenesulfonate; potassium hexamethylsilazane; sodium cyanoborohydride; acetic acid; citric acid; Lindlar's catalyst; In tetrahydrofuran; methanol; dichloromethane; acetone; toluene; acetonitrile; tert-butyl alcohol; benzene;
DOI:10.1039/b516311k

Reference yield:

: 870527-70-1
(2R,4S,5R)-(-)-5-azido-4-isopropyl-2-phenyl[1,3]dioxane

: 876952-13-5
(S)-1-((2S,3S,4R)-3-hydroxy-2-hydroxymethyl-4-methyl-5-oxo-pyrrolidin-2-yl)-2-methyl-propyl benzoate

Guidance literature:: Multi-step reaction with 11 steps

1: 100 percent / H₂ / Lindlar catalyst / methanol / 20 °C

2: MnO₂; 4 Angstroem molecular sieves / CH₂Cl₂ / Heating

3: NaCNBH₃; AcOH / methanol / 0 °C

4: 83 percent / KHMDS / tetrahydrofuran; toluene / 6 h / -30 °C

5: 93 percent / TPAP; 4-Angstroem molecular sieves; NMO / acetonitrile

6: aq. NaClO₂; NaH₂PO₄; 2-methyl-2-butene / 2-methyl-propan-2-ol / 0 °C

7: NaBH₄ / methanol / 20 °C

8: 96 percent / K₂OsO₂(OH)4; aq. citric acid; NMO / 2-methyl-propan-2-ol / 20 °C

9: 100 percent / tetrahydrofuran / Heating

10: n-Bu₃SnH; AIBN / toluene / Heating

11: 90 percent / dimethyldioxirane / acetone / 18 h / 0 - 3 °C

With manganese(IV) oxide; sodium chlorite; sodium tetrahydroborate; sodium dihydrogenphosphate; N-methyl-2-indolinone; tetrapropylammonium perruthennate; 2-methyl-but-2-ene; potassium dioxotetrahydroxoosmate(VI); 2,2'-azobis(isobutyronitrile); 4 A molecular sieve; hydrogen; tri-n-butyl-tin hydride; 3,3-dimethyldioxirane; potassium hexamethylsilazane; sodium cyanoborohydride; acetic acid; citric acid; Lindlar's catalyst; In tetrahydrofuran; methanol; dichloromethane; acetone; toluene; acetonitrile; tert-butyl alcohol;
DOI:10.1039/b516311k