ethyl 3-(3-(5-(3,4-difluorobenzylcarbamoyl)-2-fluorophenylcarbamoyl)imidazo[1,2-a]pyridin-7-yl)propanoate

Base Information

Chemical Name:ethyl 3-(3-(5-(3,4-difluorobenzylcarbamoyl)-2-fluorophenylcarbamoyl)imidazo[1,2-a]pyridin-7-yl)propanoate
CAS No.:1426531-18-1
Molecular Formula:C₂₇H₂₃F₃N₄O₄
Molecular Weight:524.499
Hs Code.:

Synonyms:ethyl 3-(3-(5-(3,4-difluorobenzylcarbamoyl)-2-fluorophenylcarbamoyl)imidazo[1,2-a]pyridin-7-yl)propanoate

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Chemical Property of ethyl 3-(3-(5-(3,4-difluorobenzylcarbamoyl)-2-fluorophenylcarbamoyl)imidazo[1,2-a]pyridin-7-yl)propanoate

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Technology Process of ethyl 3-(3-(5-(3,4-difluorobenzylcarbamoyl)-2-fluorophenylcarbamoyl)imidazo[1,2-a]pyridin-7-yl)propanoate

There total 4 articles about ethyl 3-(3-(5-(3,4-difluorobenzylcarbamoyl)-2-fluorophenylcarbamoyl)imidazo[1,2-a]pyridin-7-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1426531-08-9
7-bromo-N-(5-(3,4-difluorobenzylcarbamoyl)-2-fluorophenyl)imidazo[1,2-a]pyridine-3-carboxamide

: 193065-68-8
(3-ethoxy-3-oxopropyl)zinc(II) bromide

: 1426531-18-1
ethyl 3-(3-(5-(3,4-difluorobenzylcarbamoyl)-2-fluorophenylcarbamoyl)imidazo[1,2-a]pyridin-7-yl)propanoate

Guidance literature:: 7-bromo-N-(5-(3,4-difluorobenzylcarbamoyl)-2-fluorophenyl)imidazo[1,2-a]pyridine-3-carboxamide; With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri tert-butylphosphoniumtetrafluoroborate; In tetrahydrofuran; Inert atmosphere;

(3-ethoxy-3-oxopropyl)zinc(II) bromide; In tetrahydrofuran; at 60 ℃; for 1.66667h;

Reference yield:

: 72235-53-1
3,4-difluorobenzylamine

: 1426531-18-1
ethyl 3-(3-(5-(3,4-difluorobenzylcarbamoyl)-2-fluorophenylcarbamoyl)imidazo[1,2-a]pyridin-7-yl)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine / tetrahydrofuran / 80 °C

2.1: thionyl chloride / 1.5 h / 100 °C

2.2: 1 h / 20 °C

3.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri tert-butylphosphoniumtetrafluoroborate / tetrahydrofuran / Inert atmosphere

3.2: 1.67 h / 60 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; thionyl chloride; 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine; tri tert-butylphosphoniumtetrafluoroborate; In tetrahydrofuran;

Reference yield:

: 1305089-87-5
3-amino-N-(3,4-difluorobenzyl)-4-fluorobenzamide

: 1426531-18-1
ethyl 3-(3-(5-(3,4-difluorobenzylcarbamoyl)-2-fluorophenylcarbamoyl)imidazo[1,2-a]pyridin-7-yl)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: thionyl chloride / 1.5 h / 100 °C

1.2: 1 h / 20 °C

2.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri tert-butylphosphoniumtetrafluoroborate / tetrahydrofuran / Inert atmosphere

2.2: 1.67 h / 60 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; thionyl chloride; tri tert-butylphosphoniumtetrafluoroborate; In tetrahydrofuran;