5,7-bis[(4-(trifluoromethyl)phenyl)methyl]-2-chloro-1,3-diaza-2-phospha-tricyclo[3.3.1.1^3,7]decane-6-one 2-oxide

Base Information

• Chemical Name: 5,7-bis[(4-(trifluoromethyl)phenyl)methyl]-2-chloro-1,3-diaza-2-phospha-tricyclo[3.3.1.1^3,7]decane-6-one 2-oxide
• CAS No.: 1604777-49-2
• Molecular Formula: C₂₃H₂₀ClF₆N₂O₂P
• Molecular Weight: 536.841

Synonyms:5,7-bis[(4-(trifluoromethyl)phenyl)methyl]-2-chloro-1,3-diaza-2-phospha-tricyclo[3.3.1.1^3,7]decane-6-one 2-oxide

Chemical Property of 5,7-bis[(4-(trifluoromethyl)phenyl)methyl]-2-chloro-1,3-diaza-2-phospha-tricyclo[3.3.1.1^3,7]decane-6-one 2-oxide

Chemical Property:

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Technology Process of 5,7-bis[(4-(trifluoromethyl)phenyl)methyl]-2-chloro-1,3-diaza-2-phospha-tricyclo[3.3.1.1^3,7]decane-6-one 2-oxide

There total 3 articles about 5,7-bis[(4-(trifluoromethyl)phenyl)methyl]-2-chloro-1,3-diaza-2-phospha-tricyclo[3.3.1.1^3,7]decane-6-one 2-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

5,7-bis[[4-(trifluoromethyl)phenyl]methyl]-1,3-diazatricyclo[3.3.1.13,7]decan-6-one (1053242-58-2) → 5,7-bis[(4-(trifluoromethyl)phenyl)methyl]-2-chloro-1,3-diaza-2-phospha-tricyclo[3.3.1.13,7]decane-6-one 2-oxide (1604777-49-2)

Guidance literature:

With pyridine; trichlorophosphate; In acetonitrile; at 20 ℃; Reflux;

DOI:10.2174/15734064113099900002

Reference yield:

1,5-bis[4-(trifluoromethyl)phenyl]-3-pentanone (1053242-55-9) → 5,7-bis[(4-(trifluoromethyl)phenyl)methyl]-2-chloro-1,3-diaza-2-phospha-tricyclo[3.3.1.13,7]decane-6-one 2-oxide (1604777-49-2)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid / ethanol / 15 h / Reflux

2: pyridine; trichlorophosphate / acetonitrile / 20 °C / Reflux

With pyridine; acetic acid; trichlorophosphate; In ethanol; acetonitrile; 1: |Mannich Aminomethylation;

DOI:10.2174/15734064113099900002

Reference yield:

4-(trifluoromethyl)benzylic alcohol (349-95-1) → 5,7-bis[(4-(trifluoromethyl)phenyl)methyl]-2-chloro-1,3-diaza-2-phospha-tricyclo[3.3.1.13,7]decane-6-one 2-oxide (1604777-49-2)

Guidance literature:

Multi-step reaction with 3 steps

1: bis(1,5-cyclooctadiene)diiridium(I) dichloride; triphenylphosphine; potassium hydroxide / 100 °C

2: acetic acid / ethanol / 15 h / Reflux

3: pyridine; trichlorophosphate / acetonitrile / 20 °C / Reflux

With pyridine; bis(1,5-cyclooctadiene)diiridium(I) dichloride; acetic acid; triphenylphosphine; potassium hydroxide; trichlorophosphate; In ethanol; acetonitrile; 2: |Mannich Aminomethylation;

DOI:10.2174/15734064113099900002

upstream raw materials:

5,7-bis[[4-(trifluoromethyl)phenyl]methyl]-1,3-diazatricyclo[3.3.1.1^3,7]decan-6-one

4-(trifluoromethyl)benzylic alcohol

1,5-bis[4-(trifluoromethyl)phenyl]-3-pentanone

Downstream raw materials:

sodium 5,7-bis[(4-(trifluoromethyl)phenyl)methyl]-6-oxo-1,3-diaza-2-phospha-tricyclo[3.3.1.1^3,7]decan-2-olate 2-oxide

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