5-<<4-<<3-(N-isopropylamino)-2-hydroxypropyl>oxy>indole-2-carboxamido>methyl>-2-butyl-1-<(2'-carbomethoxybiphenyl-4-yl)methyl>-4-chloroimidazole

Base Information

• Chemical Name: 5-<<4-<<3-(N-isopropylamino)-2-hydroxypropyl>oxy>indole-2-carboxamido>methyl>-2-butyl-1-<(2'-carbomethoxybiphenyl-4-yl)methyl>-4-chloroimidazole
• CAS No.: 128764-56-7
• Molecular Formula: C₃₈H₄₄ClN₅O₅
• Molecular Weight: 686.251
• Mol file: 128764-56-7.mol

Synonyms:5-<<4-<<3-(N-isopropylamino)-2-hydroxypropyl>oxy>indole-2-carboxamido>methyl>-2-butyl-1-<(2'-carbomethoxybiphenyl-4-yl)methyl>-4-chloroimidazole

Chemical Property of 5-<<4-<<3-(N-isopropylamino)-2-hydroxypropyl>oxy>indole-2-carboxamido>methyl>-2-butyl-1-<(2'-carbomethoxybiphenyl-4-yl)methyl>-4-chloroimidazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-<<4-<<3-(N-isopropylamino)-2-hydroxypropyl>oxy>indole-2-carboxamido>methyl>-2-butyl-1-<(2'-carbomethoxybiphenyl-4-yl)methyl>-4-chloroimidazole

There total 15 articles about 5-<<4-<<3-(N-isopropylamino)-2-hydroxypropyl>oxy>indole-2-carboxamido>methyl>-2-butyl-1-<(2'-carbomethoxybiphenyl-4-yl)methyl>-4-chloroimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-<<4-<<3--2-hydroxypropyl>oxy>indole-2-carboxamido>methyl>-2-butyl-1-<(2'-carbomethoxybiphenyl-4-yl)methyl>-4-chloroimidazole (128764-55-6) → 5-<<4-<<3-(N-isopropylamino)-2-hydroxypropyl>oxy>indole-2-carboxamido>methyl>-2-butyl-1-<(2'-carbomethoxybiphenyl-4-yl)methyl>-4-chloroimidazole (128764-56-7)

Guidance literature:

With methoxybenzene; trifluoroacetic acid; In tetrahydrofuran; water; at 25 ℃; for 7h;

DOI:10.1021/jm00112a031

Reference yield:

2-(2-methoxyphenyl)-4,4-dimethyl-2-oxazoline (57598-33-1) → 5-<<4-<<3-(N-isopropylamino)-2-hydroxypropyl>oxy>indole-2-carboxamido>methyl>-2-butyl-1-<(2'-carbomethoxybiphenyl-4-yl)methyl>-4-chloroimidazole (128764-56-7)

Guidance literature:

Multi-step reaction with 10 steps

1: tetrahydrofuran / 2 h / 20 °C

2: 88 percent / 4.5 N aq. HCl / 12 h / Heating

3: 1.) acetyl chloride / 1.) 0 deg C, 0.25 h, 2.) reflux, 4 h

4: N-bromosuccinimide, dibenzoyl peroxide / CCl₄ / 3 h / Heating

5: 1.) sodium methoxide / 1.) DMF, 25 deg C, 0.25 h, 2.) DMF, 40 deg C, 4 h

6: 97 percent / thionyl chloride / CHCl₃ / 4 h / 25 °C

7: sodium azide / dimethylsulfoxide / 16 h / 25 °C

8: H₂ / 10percent Pd/C / methanol / 1 h / 25 °C / 760 Torr

9: 75 percent / 1-hydroxybenzotriazole, dicyclohexylcarbodiimide, dicyclohexylcarbodiimide / 96 h / 0 °C

10: 1.68 g / anisole, trifluoroacetic acid / tetrahydrofuran; H₂O / 7 h / 25 °C

With hydrogenchloride; N-Bromosuccinimide; thionyl chloride; sodium azide; hydrogen; sodium methylate; benzotriazol-1-ol; methoxybenzene; acetyl chloride; dicyclohexyl-carbodiimide; trifluoroacetic acid; dibenzoyl peroxide; palladium on activated charcoal; In tetrahydrofuran; methanol; tetrachloromethane; chloroform; water; dimethyl sulfoxide;

DOI:10.1021/jm00112a031

Reference yield:

4-tolyl iodide (624-31-7) → 5-<<4-<<3-(N-isopropylamino)-2-hydroxypropyl>oxy>indole-2-carboxamido>methyl>-2-butyl-1-<(2'-carbomethoxybiphenyl-4-yl)methyl>-4-chloroimidazole (128764-56-7)

Guidance literature:

Multi-step reaction with 8 steps

1: 11 percent / Cu / 1 h / 210 °C

2: N-bromosuccinimide, dibenzoyl peroxide / CCl₄ / 3 h / Heating

3: 1.) sodium methoxide / 1.) DMF, 25 deg C, 0.25 h, 2.) DMF, 40 deg C, 4 h

4: 97 percent / thionyl chloride / CHCl₃ / 4 h / 25 °C

5: sodium azide / dimethylsulfoxide / 16 h / 25 °C

6: H₂ / 10percent Pd/C / methanol / 1 h / 25 °C / 760 Torr

7: 75 percent / 1-hydroxybenzotriazole, dicyclohexylcarbodiimide, dicyclohexylcarbodiimide / 96 h / 0 °C

8: 1.68 g / anisole, trifluoroacetic acid / tetrahydrofuran; H₂O / 7 h / 25 °C

With N-Bromosuccinimide; thionyl chloride; sodium azide; hydrogen; sodium methylate; copper; benzotriazol-1-ol; methoxybenzene; dicyclohexyl-carbodiimide; trifluoroacetic acid; dibenzoyl peroxide; palladium on activated charcoal; In tetrahydrofuran; methanol; tetrachloromethane; chloroform; water; dimethyl sulfoxide;

DOI:10.1021/jm00112a031

upstream raw materials:

5-<<4-<<3--2-hydroxypropyl>oxy>indole-2-carboxamido>methyl>-2-butyl-1-<(2'-carbomethoxybiphenyl-4-yl)methyl>-4-chloroimidazole

2-(2-methoxyphenyl)-4,4-dimethyl-2-oxazoline

4-tolyl iodide

o-iodo-methyl-benzoic acid

Downstream raw materials:

5-<<4-<<3-(N-isopropylamino)-2-hydroxypropyl>oxy>indole-2-carboxamido>methyl>-2-butyl-1-<(2'-carboxybiphenyl-4-yl)methyl>-4-chloroimidazole

Refernces

• 1、 -. "Combination β-blocking/angiotensin II blocking antihypertensives". . . Retrieved 2008/06/13.