tert-butyl 5-((2-(3-(2-(isopropylamino)-2-oxoethoxy)phenyl)pyrimidin-4-yl)(methyl)amino)-1H-indazole-1-carboxylate

Base Information

• Chemical Name: tert-butyl 5-((2-(3-(2-(isopropylamino)-2-oxoethoxy)phenyl)pyrimidin-4-yl)(methyl)amino)-1H-indazole-1-carboxylate
• CAS No.: 1595291-16-9
• Molecular Formula: C₂₈H₃₂N₆O₄
• Molecular Weight: 516.6
• Mol file: 1595291-16-9.mol

Synonyms:tert-butyl 5-((2-(3-(2-(isopropylamino)-2-oxoethoxy)phenyl)pyrimidin-4-yl)(methyl)amino)-1H-indazole-1-carboxylate

Chemical Property of tert-butyl 5-((2-(3-(2-(isopropylamino)-2-oxoethoxy)phenyl)pyrimidin-4-yl)(methyl)amino)-1H-indazole-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 5-((2-(3-(2-(isopropylamino)-2-oxoethoxy)phenyl)pyrimidin-4-yl)(methyl)amino)-1H-indazole-1-carboxylate

There total 4 articles about tert-butyl 5-((2-(3-(2-(isopropylamino)-2-oxoethoxy)phenyl)pyrimidin-4-yl)(methyl)amino)-1H-indazole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-bromo-N-isopropylacetamide (75726-96-4) → tert-butyl 5-((2-(3-(2-(isopropylamino)-2-oxoethoxy)phenyl)pyrimidin-4-yl)(methyl)amino)-1H-indazole-1-carboxylate (1595291-16-9)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

2: potassium phosphate; tri-tert-butyl phosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; di-tert-butyl dicarbonate / 1,4-dioxane; water / 24 h / 100 °C

With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine; di-tert-butyl dicarbonate; potassium carbonate; In 1,4-dioxane; water; N,N-dimethyl-formamide;

Reference yield:

tert-butyl 5-((2-chloropyrimidin-4-yl)(methyl)amino)-1H-indazole-1-carboxylate (1152262-04-8) + N-isopropyl-2-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)acetamide (1595290-47-3) → tert-butyl 5-((2-(3-(2-(isopropylamino)-2-oxoethoxy)phenyl)pyrimidin-4-yl)(methyl)amino)-1H-indazole-1-carboxylate (1595291-16-9)

Guidance literature:

With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine; di-tert-butyl dicarbonate; In 1,4-dioxane; water; at 100 ℃; for 24h;

Reference yield:

N-(2-chloropyrimidin-4-yl)-N-methyl-1H-indazol-5-amine (1595291-13-6) → tert-butyl 5-((2-(3-(2-(isopropylamino)-2-oxoethoxy)phenyl)pyrimidin-4-yl)(methyl)amino)-1H-indazole-1-carboxylate (1595291-16-9)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine; dmap / dichloromethane / 1 h / 20 °C

2: potassium phosphate; tri-tert-butyl phosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; di-tert-butyl dicarbonate / 1,4-dioxane; water / 24 h / 100 °C

With dmap; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine; di-tert-butyl dicarbonate; triethylamine; In 1,4-dioxane; dichloromethane; water;

upstream raw materials:

N-(2-chloropyrimidin-4-yl)-N-methyl-1H-indazol-5-amine

(1H-indazol-5-yl)-methyl-amine

tert-butyl 5-((2-chloropyrimidin-4-yl)(methyl)amino)-1H-indazole-1-carboxylate

N-isopropyl-2-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)acetamide