(2R,3R,4R)-benzyl 3,4-bis(benzyloxy)-2-(hydroxymethyl)piperidine-1-carboxylate

Base Information

Chemical Name:(2R,3R,4R)-benzyl 3,4-bis(benzyloxy)-2-(hydroxymethyl)piperidine-1-carboxylate
CAS No.:1430587-89-5
Molecular Formula:C₂₈H₃₁NO₅
Molecular Weight:461.558
Hs Code.:

Synonyms:(2R,3R,4R)-benzyl 3,4-bis(benzyloxy)-2-(hydroxymethyl)piperidine-1-carboxylate

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Chemical Property of (2R,3R,4R)-benzyl 3,4-bis(benzyloxy)-2-(hydroxymethyl)piperidine-1-carboxylate

Chemical Property:

Purity/Quality:

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Technology Process of (2R,3R,4R)-benzyl 3,4-bis(benzyloxy)-2-(hydroxymethyl)piperidine-1-carboxylate

There total 3 articles about (2R,3R,4R)-benzyl 3,4-bis(benzyloxy)-2-(hydroxymethyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₈H₂₉NO₅

: 1430587-89-5
(2R,3R,4R)-benzyl 3,4-bis(benzyloxy)-2-(hydroxymethyl)piperidine-1-carboxylate

Guidance literature:: With sodium tetrahydroborate; at -78 - 0 ℃; for 2h; Inert atmosphere;
DOI:10.1016/j.tet.2013.03.046

Reference yield:

: benzyl (3R,4R,5R)-4,5-bis(benzyloxy)-7-bromo-1-phenylhept-1-en-3-ylcarbamate

: 1430587-89-5
(2R,3R,4R)-benzyl 3,4-bis(benzyloxy)-2-(hydroxymethyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium tert-butylate / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere

2: ozone / methanol; dichloromethane / 3 h / -78 °C / Inert atmosphere

3: sodium tetrahydroborate / 2 h / -78 - 0 °C / Inert atmosphere

With sodium tetrahydroborate; potassium tert-butylate; ozone; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/j.tet.2013.03.046

Reference yield:

: (2R,3R,4R)-benzyl 3,4-bis(benzyloxy)-2-styrylpiperidine-1-carboxylate

: 1430587-89-5
(2R,3R,4R)-benzyl 3,4-bis(benzyloxy)-2-(hydroxymethyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: ozone / methanol; dichloromethane / 3 h / -78 °C / Inert atmosphere

2: sodium tetrahydroborate / 2 h / -78 - 0 °C / Inert atmosphere

With sodium tetrahydroborate; ozone; In methanol; dichloromethane;
DOI:10.1016/j.tet.2013.03.046