(2S,3aS,6R,7aS)-1-((2R,3S)-2-((R)-3-(4-(benzyloxy)phenyl)-2-((triisopropylsilyl)oxy)propanamido)-3-methylpentanoyl)-N-(4-(2,3-dibenzyloxycarbonyl)guanidinobutyl)-6-hydroxyoctahydro-1H-indole-2-carboxamide

Base Information

Chemical Name:(2S,3aS,6R,7aS)-1-((2R,3S)-2-((R)-3-(4-(benzyloxy)phenyl)-2-((triisopropylsilyl)oxy)propanamido)-3-methylpentanoyl)-N-(4-(2,3-dibenzyloxycarbonyl)guanidinobutyl)-6-hydroxyoctahydro-1H-indole-2-carboxamide
CAS No.:1412914-82-9
Molecular Formula:C₆₁H₈₄N₆O₁₀Si
Molecular Weight:1089.46
Hs Code.:

(2S,3aS,6R,7aS)-1-((2R,3S)-2-((R)-3-(4-(benzyloxy)phenyl)-2-((triisopropylsilyl)oxy)propanamido)-3-methylpentanoyl)-N-(4-(2,3-dibenzyloxycarbonyl)guanidinobutyl)-6-hydroxyoctahydro-1H-indole-2-carboxamide

Synonyms:(2S,3aS,6R,7aS)-1-((2R,3S)-2-((R)-3-(4-(benzyloxy)phenyl)-2-((triisopropylsilyl)oxy)propanamido)-3-methylpentanoyl)-N-(4-(2,3-dibenzyloxycarbonyl)guanidinobutyl)-6-hydroxyoctahydro-1H-indole-2-carboxamide

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Chemical Property of (2S,3aS,6R,7aS)-1-((2R,3S)-2-((R)-3-(4-(benzyloxy)phenyl)-2-((triisopropylsilyl)oxy)propanamido)-3-methylpentanoyl)-N-(4-(2,3-dibenzyloxycarbonyl)guanidinobutyl)-6-hydroxyoctahydro-1H-indole-2-carboxamide

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Technology Process of (2S,3aS,6R,7aS)-1-((2R,3S)-2-((R)-3-(4-(benzyloxy)phenyl)-2-((triisopropylsilyl)oxy)propanamido)-3-methylpentanoyl)-N-(4-(2,3-dibenzyloxycarbonyl)guanidinobutyl)-6-hydroxyoctahydro-1H-indole-2-carboxamide

There total 12 articles about (2S,3aS,6R,7aS)-1-((2R,3S)-2-((R)-3-(4-(benzyloxy)phenyl)-2-((triisopropylsilyl)oxy)propanamido)-3-methylpentanoyl)-N-(4-(2,3-dibenzyloxycarbonyl)guanidinobutyl)-6-hydroxyoctahydro-1H-indole-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₄₀H₆₀N₂O₇Si

: N-(4-aminobutyl)-1,2-bis(benzyloxycarbonyl)guanidine

: 1412914-82-9
(2S,3aS,6R,7aS)-1-((2R,3S)-2-((R)-3-(4-(benzyloxy)phenyl)-2-((triisopropylsilyl)oxy)propanamido)-3-methylpentanoyl)-N-(4-(2,3-dibenzyloxycarbonyl)guanidinobutyl)-6-hydroxyoctahydro-1H-indole-2-carboxamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; N,N-dimethyl-formamide; at 0 - 20 ℃; for 4h; Inert atmosphere;
DOI:10.1021/ja309947n

Reference yield:

: 1412914-77-2
6-hydroxy-2,3,5,6,7,7a-hexahydro-1-benzylindole-2-carboxylic acid methyl ester

: 1412914-82-9
(2S,3aS,6R,7aS)-1-((2R,3S)-2-((R)-3-(4-(benzyloxy)phenyl)-2-((triisopropylsilyl)oxy)propanamido)-3-methylpentanoyl)-N-(4-(2,3-dibenzyloxycarbonyl)guanidinobutyl)-6-hydroxyoctahydro-1H-indole-2-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: 5%-palladium/activated carbon; hydrogen / 18 h / 20 °C / Inert atmosphere

2: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 6 h / 0 - 20 °C / Inert atmosphere

3: water; lithium hydroxide / methanol; tetrahydrofuran / 20 h / 20 °C / Inert atmosphere

4: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane; N,N-dimethyl-formamide / 4 h / 0 - 20 °C / Inert atmosphere

With 5%-palladium/activated carbon; water; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja309947n

Reference yield:

: 373368-56-0
Methyl (2S,3aS,6R,7aS)-6-hydroxy-octahydroindole-2-carboxylate

: 1412914-82-9
(2S,3aS,6R,7aS)-1-((2R,3S)-2-((R)-3-(4-(benzyloxy)phenyl)-2-((triisopropylsilyl)oxy)propanamido)-3-methylpentanoyl)-N-(4-(2,3-dibenzyloxycarbonyl)guanidinobutyl)-6-hydroxyoctahydro-1H-indole-2-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 6 h / 0 - 20 °C / Inert atmosphere

2: water; lithium hydroxide / methanol; tetrahydrofuran / 20 h / 20 °C / Inert atmosphere

3: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane; N,N-dimethyl-formamide / 4 h / 0 - 20 °C / Inert atmosphere

With water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja309947n