5'-azido-N₆-benzoyl-5'-deoxy-2'-O-(triisopropylsilyloxymethyl)adenosine

Base Information

Chemical Name:5'-azido-N₆-benzoyl-5'-deoxy-2'-O-(triisopropylsilyloxymethyl)adenosine
CAS No.:1287721-53-2
Molecular Formula:C₂₇H₃₈N₈O₅Si
Molecular Weight:582.735
Hs Code.:

5'-azido-N<sub>6</sub>-benzoyl-5'-deoxy-2'-O-(triisopropylsilyloxymethyl)adenosine

Synonyms:5'-azido-N₆-benzoyl-5'-deoxy-2'-O-(triisopropylsilyloxymethyl)adenosine

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Chemical Property of 5'-azido-N₆-benzoyl-5'-deoxy-2'-O-(triisopropylsilyloxymethyl)adenosine

Chemical Property:

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Technology Process of 5'-azido-N₆-benzoyl-5'-deoxy-2'-O-(triisopropylsilyloxymethyl)adenosine

There total 1 articles about 5'-azido-N₆-benzoyl-5'-deoxy-2'-O-(triisopropylsilyloxymethyl)adenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 57610-04-5
N⁶-benzoyl-5'-azidoadenosine

: 217300-17-9
chloromethoxy-triisopropyl-silane

: 1287721-53-2
5'-azido-N₆-benzoyl-5'-deoxy-2'-O-(triisopropylsilyloxymethyl)adenosine

Guidance literature:: N⁶-benzoyl-5'-azidoadenosine; With dibutyltin chloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;

chloromethoxy-triisopropyl-silane; In dichloromethane; at 80 ℃; for 0.5h; Inert atmosphere;
DOI:10.1002/anie.201007012

Reference yield: 71.0%

: 1287721-53-2
5'-azido-N₆-benzoyl-5'-deoxy-2'-O-(triisopropylsilyloxymethyl)adenosine

: 1287721-54-3
5'-amino-N₆-benzoyl-5'-deoxy-2'-O-(triisopropylsilyloxymethyl)adenosine

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 14h;
DOI:10.1002/anie.201007012

Reference yield:

: 1287721-53-2
5'-azido-N₆-benzoyl-5'-deoxy-2'-O-(triisopropylsilyloxymethyl)adenosine

: 1287721-55-4
C₆₀H₇₀N₈O₁₃Si

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 14 h / 20 °C

2: benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane; acetonitrile / 12 h / 20 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; acetonitrile;
DOI:10.1002/anie.201007012