methanesulfonic acid 1-{3-(2-hydroxy-ethyl)-4-[(2-iodo-phenyl)-methanesulfonyl-amino]-cyclohex-2-enyl}-ethyl ester

Base Information

Chemical Name:methanesulfonic acid 1-{3-(2-hydroxy-ethyl)-4-[(2-iodo-phenyl)-methanesulfonyl-amino]-cyclohex-2-enyl}-ethyl ester
CAS No.:311309-59-8
Molecular Formula:C₁₈H₂₆INO₆S₂
Molecular Weight:543.444
Hs Code.:

Synonyms:methanesulfonic acid 1-{3-(2-hydroxy-ethyl)-4-[(2-iodo-phenyl)-methanesulfonyl-amino]-cyclohex-2-enyl}-ethyl ester

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Chemical Property of methanesulfonic acid 1-{3-(2-hydroxy-ethyl)-4-[(2-iodo-phenyl)-methanesulfonyl-amino]-cyclohex-2-enyl}-ethyl ester

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Technology Process of methanesulfonic acid 1-{3-(2-hydroxy-ethyl)-4-[(2-iodo-phenyl)-methanesulfonyl-amino]-cyclohex-2-enyl}-ethyl ester

There total 8 articles about methanesulfonic acid 1-{3-(2-hydroxy-ethyl)-4-[(2-iodo-phenyl)-methanesulfonyl-amino]-cyclohex-2-enyl}-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 311309-58-7
methanesulfonic acid 1-[4-[(2-iodo-phenyl)-methanesulfonyl-amino]-3-(2-oxo-ethyl)-cyclohex-2-enyl]-ethyl ester

: 311309-59-8
methanesulfonic acid 1-{3-(2-hydroxy-ethyl)-4-[(2-iodo-phenyl)-methanesulfonyl-amino]-cyclohex-2-enyl}-ethyl ester

Guidance literature:: With sodium tetrahydroborate; In methanol; for 0.333333h;
DOI:10.1021/ol006477x

Reference yield:

: 143675-84-7
3-isobutoxy-2-(2-propenyl)-2-cyclohexenone

: 311309-59-8
methanesulfonic acid 1-{3-(2-hydroxy-ethyl)-4-[(2-iodo-phenyl)-methanesulfonyl-amino]-cyclohex-2-enyl}-ethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 72 percent / LDA

2: 83 percent / Et₃N; DMAP / CH₂Cl₂

3: 67 percent / DIBAL-H / CH₂Cl₂

4: 67 percent / NaBH₄; CeCl₃*7H₂O / methanol

5: 51 percent / Me₃P; DIAD; pyridine / tetrahydrofuran

6: 78 percent / OsO₄; NMO / acetone; H₂O; 2-methyl-propan-2-ol

7: 65 percent / NaIO₄ / H₂O; diethyl ether; ethanol

8: 95 percent / NaBH₄ / methanol / 0.33 h

With pyridine; dmap; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; N-methyl-2-indolinone; cerium(III) chloride; di-isopropyl azodicarboxylate; diisobutylaluminium hydride; triethylamine; lithium diisopropyl amide; trimethylphosphane; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; water; acetone; tert-butyl alcohol; 1: aldol condensation / 2: Substitution / 3: Reduction / 4: Reduction / 5: Mitsunobu reaction / 6: Oxidation / 7: Oxidation / 8: Reduction;
DOI:10.1021/ol006477x

Reference yield:

: 311309-49-6
methanesulfonic acid 1-(3-allyl-4-oxo-cyclohex-2-enyl)-ethyl ester

: 311309-59-8
methanesulfonic acid 1-{3-(2-hydroxy-ethyl)-4-[(2-iodo-phenyl)-methanesulfonyl-amino]-cyclohex-2-enyl}-ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 67 percent / NaBH₄; CeCl₃*7H₂O / methanol

2: 51 percent / Me₃P; DIAD; pyridine / tetrahydrofuran

3: 78 percent / OsO₄; NMO / acetone; H₂O; 2-methyl-propan-2-ol

4: 65 percent / NaIO₄ / H₂O; diethyl ether; ethanol

5: 95 percent / NaBH₄ / methanol / 0.33 h

With pyridine; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; N-methyl-2-indolinone; cerium(III) chloride; di-isopropyl azodicarboxylate; trimethylphosphane; In tetrahydrofuran; methanol; diethyl ether; ethanol; water; acetone; tert-butyl alcohol; 1: Reduction / 2: Mitsunobu reaction / 3: Oxidation / 4: Oxidation / 5: Reduction;
DOI:10.1021/ol006477x