ethyl 4-(2-(4-(2-oxo-2-(thiazol-2-ylamino)ethyl)piperazin-1-yl)ethoxy)benzoate

Base Information

Chemical Name:ethyl 4-(2-(4-(2-oxo-2-(thiazol-2-ylamino)ethyl)piperazin-1-yl)ethoxy)benzoate
CAS No.:1352874-97-5
Molecular Formula:C₂₀H₂₆N₄O₄S
Molecular Weight:418.517
Hs Code.:

Synonyms:ethyl 4-(2-(4-(2-oxo-2-(thiazol-2-ylamino)ethyl)piperazin-1-yl)ethoxy)benzoate

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Chemical Property of ethyl 4-(2-(4-(2-oxo-2-(thiazol-2-ylamino)ethyl)piperazin-1-yl)ethoxy)benzoate

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Technology Process of ethyl 4-(2-(4-(2-oxo-2-(thiazol-2-ylamino)ethyl)piperazin-1-yl)ethoxy)benzoate

There total 3 articles about ethyl 4-(2-(4-(2-oxo-2-(thiazol-2-ylamino)ethyl)piperazin-1-yl)ethoxy)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.61%

: 133311-45-2
ethyl 4-[2-(1-piperazinyl)ethoxy]benzoate

: 5448-49-7
2-chloro-N-(1,3-thiazol-2-yl)acetamide

: 1352874-97-5
ethyl 4-(2-(4-(2-oxo-2-(thiazol-2-ylamino)ethyl)piperazin-1-yl)ethoxy)benzoate

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 8h;
DOI:10.1016/j.ejmech.2014.03.075

Reference yield:

: 120-47-8
Ethyl 4-hydroxybenzoate

: 1352874-97-5
ethyl 4-(2-(4-(2-oxo-2-(thiazol-2-ylamino)ethyl)piperazin-1-yl)ethoxy)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetonitrile / 24 h / 50 °C / Reflux

2: hydrogen bromide / water; ethanol / 48 h / 20 °C / Reflux

3: triethylamine / dichloromethane / 8 h / 0 - 20 °C

With hydrogen bromide; potassium carbonate; triethylamine; In ethanol; dichloromethane; water; acetonitrile;
DOI:10.1016/j.ejmech.2014.03.075

Reference yield:

: 41386-38-3
4-(2-Bromo-ethoxy)-benzoic acid ethyl ester

: 1352874-97-5
ethyl 4-(2-(4-(2-oxo-2-(thiazol-2-ylamino)ethyl)piperazin-1-yl)ethoxy)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen bromide / water; ethanol / 48 h / 20 °C / Reflux

2: triethylamine / dichloromethane / 8 h / 0 - 20 °C

With hydrogen bromide; triethylamine; In ethanol; dichloromethane; water;
DOI:10.1016/j.ejmech.2014.03.075