N--4-cyano-D-phenylalanine piperidide

Base Information

Chemical Name:N--4-cyano-D-phenylalanine piperidide
CAS No.:172267-46-8
Molecular Formula:C₃₆H₄₂N₄O₇S
Molecular Weight:674.818
Hs Code.:

N-<N'-(4-methoxy-2,3,5-trimethylphenylsulfonyl)-β-(O-benzyl)-α-L-aspartyl>-4-cyano-D-phenylalanine piperidide

Synonyms:N--4-cyano-D-phenylalanine piperidide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N--4-cyano-D-phenylalanine piperidide

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Technology Process of N--4-cyano-D-phenylalanine piperidide

There total 11 articles about N--4-cyano-D-phenylalanine piperidide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 152781-30-1
D-(p-cyanophenylalanine) piperidide

: 172267-42-4
β-(O-benzyl)

: 172267-46-8
N--4-cyano-D-phenylalanine piperidide

Guidance literature:: With MEPA; In ethyl acetate; at 25 ℃; for 16h;
DOI:10.1016/0040-4020(95)00765-Z

Reference yield:

: 80745-07-9
4-methoxy-2,3,6-trimethylbenzenesulfonyl chloride

: 172267-46-8
N--4-cyano-D-phenylalanine piperidide

Guidance literature:: Multi-step reaction with 4 steps

1: 96 percent / iPr₂NH / dimethylformamide; H₂O / 4 h / 0 °C

2: 87 percent / thionyl chloride / ethyl acetate / 1.) 0 deg C to 20 deg C, 1.5 h; 2.) 20 deg C, 45 min

3: K₂CO₃ / dimethylformamide / 4 h / 20 °C

4: 76 percent / MEPA / ethyl acetate / 16 h / 25 °C

With thionyl chloride; potassium carbonate; diisopropylamine; In water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/0040-4020(95)00765-Z

Reference yield:

: 110-89-4
piperidine

: 172267-46-8
N--4-cyano-D-phenylalanine piperidide

Guidance literature:: Multi-step reaction with 3 steps

1: 70 percent / MEPA / ethyl acetate / 1 h / 25 °C

2: 85 percent / aq. HCl / 2 h / 80 °C

3: 76 percent / MEPA / ethyl acetate / 16 h / 25 °C

With hydrogenchloride; In ethyl acetate;
DOI:10.1016/0040-4020(95)00765-Z