4-[ethoxyimino-(4-fluoro-phenyl)-methyl]-piperidine-1-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: 4-[ethoxyimino-(4-fluoro-phenyl)-methyl]-piperidine-1-carboxylic acid tert-butyl ester
• CAS No.: 438208-38-9
• Molecular Formula: C₁₉H₂₇FN₂O₃
• Molecular Weight: 350.433
• Mol file: 438208-38-9.mol

Synonyms:4-[ethoxyimino-(4-fluoro-phenyl)-methyl]-piperidine-1-carboxylic acid tert-butyl ester

Chemical Property of 4-[ethoxyimino-(4-fluoro-phenyl)-methyl]-piperidine-1-carboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 4-[ethoxyimino-(4-fluoro-phenyl)-methyl]-piperidine-1-carboxylic acid tert-butyl ester

There total 2 articles about 4-[ethoxyimino-(4-fluoro-phenyl)-methyl]-piperidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

O-ethylhydroxylamine hydrochloride (3332-29-4) + tert-butyl 1-[4-(4-fluorobenzoyl)piperidin-1-yl]carboxylate (160296-40-2) → 4-[ethoxyimino-(4-fluoro-phenyl)-methyl]-piperidine-1-carboxylic acid tert-butyl ester (438208-38-9)

Guidance literature:

With sodium acetate; In methanol; at 20 ℃; for 24h;

DOI:10.1021/jm0200815

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → 4-[ethoxyimino-(4-fluoro-phenyl)-methyl]-piperidine-1-carboxylic acid tert-butyl ester (438208-38-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 10percent aq. NaOH / diethyl ether / 20 °C

2: NaOAc / methanol / 24 h / 20 °C

With sodium acetate; In methanol; diethyl ether;

DOI:10.1021/jm0200815

Reference yield:

4-[ethoxyimino-(4-fluoro-phenyl)-methyl]-piperidine-1-carboxylic acid tert-butyl ester (438208-38-9) → (4-fluoro-phenyl)-piperidin-4-yl-methanone O-ethyl-oxime

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1021/jm0200815

upstream raw materials:

O-ethylhydroxylamine hydrochloride

tert-butyl 1-[4-(4-fluorobenzoyl)piperidin-1-yl]carboxylate

di-tert-butyl dicarbonate