C₄₈H₆₁Cl₆NO₁₈

Base Information

• Chemical Name: C₄₈H₆₁Cl₆NO₁₈
• CAS No.: 1053629-62-1
• Molecular Formula: C₄₈H₆₁Cl₆NO₁₈
• Molecular Weight: 1152.73
• Mol file: 1053629-62-1.mol

Synonyms:C₄₈H₆₁Cl₆NO₁₈

Chemical Property of C₄₈H₆₁Cl₆NO₁₈

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of C₄₈H₆₁Cl₆NO₁₈

There total 4 articles about C₄₈H₆₁Cl₆NO₁₈ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

di-tert-amyl dicarbonate (68835-89-2) + 3'-tert-butyl-10-deacetyl-N-debenzoyl-3'-dephenyl-7,10-bis<<(2,2,2-trichloroethyl)oxy>carbonyl>paclitaxel (170241-01-7) → C48H61Cl6NO18 (1053629-62-1)

Guidance literature:

With sodium hydrogencarbonate; In tetrahydrofuran; at 24 ℃; for 4h;

DOI:10.1021/jm00019a012

Reference yield:

7,10-di-(2,2,2-trichloroethyloxycarbonyl)-10-deacetylbaccatin III (95603-44-4) → C48H61Cl6NO18 (1053629-62-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 71 percent / 1,3-dicyclohexylcarbodiimide, 4-(dimethylamino)pyridine / toluene / a) 60 deg C, 20 h, b) 85 deg C, 4 h

2: 62 percent / 90percent HCOOH / 24 h / Ambient temperature

3: 82 percent / aq. NaHCO₃ / tetrahydrofuran / 4 h / 24 °C

With dmap; formic acid; sodium hydrogencarbonate; dicyclohexyl-carbodiimide; In tetrahydrofuran; toluene;

DOI:10.1021/jm00019a012

Reference yield:

(4S,5R)-3-(tert-butoxycarbonyl)-4-tert-butyl-2,2-dimethyl-1,3-oxazolidine-5-carboxylic acid (170240-99-0) → C48H61Cl6NO18 (1053629-62-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 71 percent / 1,3-dicyclohexylcarbodiimide, 4-(dimethylamino)pyridine / toluene / a) 60 deg C, 20 h, b) 85 deg C, 4 h

2: 62 percent / 90percent HCOOH / 24 h / Ambient temperature

3: 82 percent / aq. NaHCO₃ / tetrahydrofuran / 4 h / 24 °C

With dmap; formic acid; sodium hydrogencarbonate; dicyclohexyl-carbodiimide; In tetrahydrofuran; toluene;

DOI:10.1021/jm00019a012

upstream raw materials:

di-tert-amyl dicarbonate

3'-tert-butyl-10-deacetyl-N-debenzoyl-3'-dephenyl-7,10-bis<<(2,2,2-trichloroethyl)oxy>carbonyl>paclitaxel

7,10-di-(2,2,2-trichloroethyloxycarbonyl)-10-deacetylbaccatin III

(4S,5R)-3-(tert-butoxycarbonyl)-4-tert-butyl-2,2-dimethyl-1,3-oxazolidine-5-carboxylic acid

Refernces