methyl N-[(10R,14S)-14-[6-(2-fluoro-3-methoxyphenyl)-2-oxo-1,3-oxazinan-3-yl]-10-methyl-9-oxo-8,16,18-triazatricyclo[13.2.1.0^2,7]octadeca-1⁽¹⁷⁾,2,4,6,15⁽¹⁸⁾-pentaen-5-yl]carbamate trifluoroacetate

Base Information

• Chemical Name: methyl N-[(10R,14S)-14-[6-(2-fluoro-3-methoxyphenyl)-2-oxo-1,3-oxazinan-3-yl]-10-methyl-9-oxo-8,16,18-triazatricyclo[13.2.1.0^2,7]octadeca-1⁽¹⁷⁾,2,4,6,15⁽¹⁸⁾-pentaen-5-yl]carbamate trifluoroacetate
• CAS No.: 1422508-30-2
• Molecular Formula: C₂HF₃O₂*C₂₉H₃₂FN₅O₆
• Molecular Weight: 679.625

Synonyms:methyl N-[(10R,14S)-14-[6-(2-fluoro-3-methoxyphenyl)-2-oxo-1,3-oxazinan-3-yl]-10-methyl-9-oxo-8,16,18-triazatricyclo[13.2.1.0^2,7]octadeca-1⁽¹⁷⁾,2,4,6,15⁽¹⁸⁾-pentaen-5-yl]carbamate trifluoroacetate

Chemical Property of methyl N-[(10R,14S)-14-[6-(2-fluoro-3-methoxyphenyl)-2-oxo-1,3-oxazinan-3-yl]-10-methyl-9-oxo-8,16,18-triazatricyclo[13.2.1.0^2,7]octadeca-1⁽¹⁷⁾,2,4,6,15⁽¹⁸⁾-pentaen-5-yl]carbamate trifluoroacetate

Chemical Property:

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Technology Process of methyl N-[(10R,14S)-14-[6-(2-fluoro-3-methoxyphenyl)-2-oxo-1,3-oxazinan-3-yl]-10-methyl-9-oxo-8,16,18-triazatricyclo[13.2.1.0^2,7]octadeca-1⁽¹⁷⁾,2,4,6,15⁽¹⁸⁾-pentaen-5-yl]carbamate trifluoroacetate

There total 19 articles about methyl N-[(10R,14S)-14-[6-(2-fluoro-3-methoxyphenyl)-2-oxo-1,3-oxazinan-3-yl]-10-methyl-9-oxo-8,16,18-triazatricyclo[13.2.1.0^2,7]octadeca-1⁽¹⁷⁾,2,4,6,15⁽¹⁸⁾-pentaen-5-yl]carbamate trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

methyl N-[(10R,14S)-14-[6-(2-fluoro-3-methoxyphenyl)-2-oxo-1,3-oxazinan-3-yl]-10-methyl-9-oxo-16-{[2-(trimethylsilyl)ethoxy]methyl}-8,16,18-triazatricyclo[13.2.1.02,7]octadeca-1(17),2,4,6,15(18)-pentaen-5-yl]carbamate (1422511-03-2) + trifluoroacetic acid (76-05-1) → methyl N-[(10R,14S)-14-[6-(2-fluoro-3-methoxyphenyl)-2-oxo-1,3-oxazinan-3-yl]-10-methyl-9-oxo-8,16,18-triazatricyclo[13.2.1.02,7]octadeca-1(17),2,4,6,15(18)-pentaen-5-yl]carbamate trifluoroacetate (1422508-30-2)

Guidance literature:

methyl N-[(10R,14S)-14-[6-(2-fluoro-3-methoxyphenyl)-2-oxo-1,3-oxazinan-3-yl]-10-methyl-9-oxo-16-{[2-(trimethylsilyl)ethoxy]methyl}-8,16,18-triazatricyclo[13.2.1.0^2,7]octadeca-1⁽¹⁷⁾,2,4,6,15⁽¹⁸⁾-pentaen-5-yl]carbamate; With hydrogenchloride; In 1,4-dioxane; at 75 ℃; for 6h;

trifluoroacetic acid;

Reference yield:

tert-butyl 3-(2-fluoro-3-methoxyphenyl)-3-hydroxypropanoate (1422510-38-0) → methyl N-[(10R,14S)-14-[6-(2-fluoro-3-methoxyphenyl)-2-oxo-1,3-oxazinan-3-yl]-10-methyl-9-oxo-8,16,18-triazatricyclo[13.2.1.02,7]octadeca-1(17),2,4,6,15(18)-pentaen-5-yl]carbamate trifluoroacetate (1422508-30-2)

Guidance literature:

Multi-step reaction with 5 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C

2.1: 1H-imidazole; triphenylphosphine; iodine / benzene / 20 °C

3.1: potassium carbonate / acetonitrile / 75 °C

4.1: tetrahydrofuran / 20 °C / Inert atmosphere

4.2: 0.25 h / 0 °C / Inert atmosphere

5.1: hydrogenchloride / 1,4-dioxane / 6 h / 75 °C

With 1H-imidazole; hydrogenchloride; lithium aluminium tetrahydride; iodine; potassium carbonate; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; acetonitrile; benzene;

Reference yield:

1-(2-fluoro-3-methoxyphenyl)-3-iodopropan-1-ol (1422510-37-9) → methyl N-[(10R,14S)-14-[6-(2-fluoro-3-methoxyphenyl)-2-oxo-1,3-oxazinan-3-yl]-10-methyl-9-oxo-8,16,18-triazatricyclo[13.2.1.02,7]octadeca-1(17),2,4,6,15(18)-pentaen-5-yl]carbamate trifluoroacetate (1422508-30-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium carbonate / acetonitrile / 75 °C

2.1: tetrahydrofuran / 20 °C / Inert atmosphere

2.2: 0.25 h / 0 °C / Inert atmosphere

3.1: hydrogenchloride / 1,4-dioxane / 6 h / 75 °C

With hydrogenchloride; potassium carbonate; In tetrahydrofuran; 1,4-dioxane; acetonitrile;

upstream raw materials:

2-fluoro-3-methoxybenzaldehyde

tert-butyl 3-(2-fluoro-3-methoxyphenyl)-3-hydroxypropanoate

1-(2-fluoro-3-methoxyphenyl)propan-1,3-diol

1-(2-fluoro-3-methoxyphenyl)-3-iodopropan-1-ol

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