1',2'-Dideoxy-1'-(2,4-difluorotoluyl)-3',5'-di-O-toluoyl-β-D-ribofuranose

Base Information

• Chemical Name: 1',2'-Dideoxy-1'-(2,4-difluorotoluyl)-3',5'-di-O-toluoyl-β-D-ribofuranose
• CAS No.: 159277-48-2
• Molecular Formula: C₂₈H₂₆F₂O₅
• Molecular Weight: 480.508
• Mol file: 159277-48-2.mol

Synonyms:1',2'-Dideoxy-1'-(2,4-difluorotoluyl)-3',5'-di-O-toluoyl-β-D-ribofuranose

Chemical Property of 1',2'-Dideoxy-1'-(2,4-difluorotoluyl)-3',5'-di-O-toluoyl-β-D-ribofuranose

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1',2'-Dideoxy-1'-(2,4-difluorotoluyl)-3',5'-di-O-toluoyl-β-D-ribofuranose

There total 4 articles about 1',2'-Dideoxy-1'-(2,4-difluorotoluyl)-3',5'-di-O-toluoyl-β-D-ribofuranose which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

C28H26F2O5 (176707-62-3) → 1',2'-Dideoxy-1'-(2,4-difluorotoluyl)-3',5'-di-O-toluoyl-β-D-ribofuranose (159277-48-2)

Guidance literature:

With sulfuric acid; benzenesulfonic acid; In toluene; for 6h; Heating;

Reference yield:

2-deoxy-3,5-di-O-p-toluoyl-α-D-erythro-pentofuranosyl chloride (4330-21-6) → 1',2'-Dideoxy-1'-(2,4-difluorotoluyl)-3',5'-di-O-toluoyl-β-D-ribofuranose (159277-48-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) Mg, I₂, 2.) CdCl₂

2: 46 percent / PhSO₃H, H₂SO₄, H₂O / toluene / 6 h / Heating

With sulfuric acid; water; iodine; magnesium; benzenesulfonic acid; cadmium(II) chloride; In toluene;

DOI:10.1021/ja9612763

Reference yield:

2-deoxy-3,5-di-O-p-toluoyl-α-D-erythro-pentofuranosyl chloride (4330-21-6) → 1',2'-Dideoxy-1'-(2,4-difluorotoluyl)-3',5'-di-O-toluoyl-β-D-ribofuranose (159277-48-2) + C28H26F2O5 (176707-62-3)

Guidance literature:

With iodine; magnesium; cadmium(II) chloride; Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1021/ja9612763

upstream raw materials:

2-deoxy-3,5-di-O-p-toluoyl-α-D-erythro-pentofuranosyl chloride

1-bromo-2,4-difluoro-5-methylbenzene

C₂₈H₂₆F₂O₅

Downstream raw materials:

1',2'-dideoxy-1'-(2,4-difluoro-5-methylphenyl)-β-D-ribofuranose

1',2'-dideoxy-1'-(2,4-difluorotolyl)-5'-O-(4,4'-dimethoxytrityl)-β-D-ribofuranose