1-(6-{4'-[4-(cyclopropylsulfonyl)piperazin-1-yl]-4-methylbiphenyl-2-yl}pyridin-2-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

Base Information

Chemical Name:1-(6-{4'-[4-(cyclopropylsulfonyl)piperazin-1-yl]-4-methylbiphenyl-2-yl}pyridin-2-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid
CAS No.:1374339-40-8
Molecular Formula:C₃₀H₂₈F₃N₅O₄S
Molecular Weight:611.645
Hs Code.:

Synonyms:1-(6-{4'-[4-(cyclopropylsulfonyl)piperazin-1-yl]-4-methylbiphenyl-2-yl}pyridin-2-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

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Chemical Property of 1-(6-{4'-[4-(cyclopropylsulfonyl)piperazin-1-yl]-4-methylbiphenyl-2-yl}pyridin-2-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

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Technology Process of 1-(6-{4'-[4-(cyclopropylsulfonyl)piperazin-1-yl]-4-methylbiphenyl-2-yl}pyridin-2-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

There total 10 articles about 1-(6-{4'-[4-(cyclopropylsulfonyl)piperazin-1-yl]-4-methylbiphenyl-2-yl}pyridin-2-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1374342-25-2
ethyl 1-{6-[4-methyl-4'-(piperazin-1-yl)biphenyl-2-yl]pyridin-2-yl}-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate

: 139631-62-2
cyclopropanesulfonyl chloride

: 1374339-40-8
1-(6-{4'-[4-(cyclopropylsulfonyl)piperazin-1-yl]-4-methylbiphenyl-2-yl}pyridin-2-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

Guidance literature:: ethyl 1-{6-[4-methyl-4'-(piperazin-1-yl)biphenyl-2-yl]pyridin-2-yl}-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate; cyclopropanesulfonyl chloride; With caesium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 1h;

With water; sodium hydroxide; In 1,4-dioxane; at 60 ℃; for 0.25h;

Reference yield:

: 1128268-25-6
ethyl 1-[6-(2-hydroxy-5-methylphenyl)pyridin-2-yl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate

: 1374339-40-8
1-(6-{4'-[4-(cyclopropylsulfonyl)piperazin-1-yl]-4-methylbiphenyl-2-yl}pyridin-2-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine / dichloromethane / 0.42 h / -78 - 20 °C

2.1: sodium carbonate; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II) / acetonitrile; water / 1 h / 85 °C / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 0.33 h

4.1: caesium carbonate / N,N-dimethyl-formamide / 1 h / 60 °C

4.2: 0.25 h / 60 °C

With pyridine; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); sodium carbonate; caesium carbonate; trifluoroacetic acid; In dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1128268-23-4
ethyl 1-[6-(2-methoxy-5-methylphenyl)pyridin-2-yl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate

: 1374339-40-8
1-(6-{4'-[4-(cyclopropylsulfonyl)piperazin-1-yl]-4-methylbiphenyl-2-yl}pyridin-2-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: boron tribromide / dichloromethane / 2.25 h / 0 - 20 °C

2.1: pyridine / dichloromethane / 0.42 h / -78 - 20 °C

3.1: sodium carbonate; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II) / acetonitrile; water / 1 h / 85 °C / Inert atmosphere

4.1: trifluoroacetic acid / dichloromethane / 0.33 h

5.1: caesium carbonate / N,N-dimethyl-formamide / 1 h / 60 °C

5.2: 0.25 h / 60 °C

With pyridine; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); boron tribromide; sodium carbonate; caesium carbonate; trifluoroacetic acid; In dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;