cyclo[2-aminoisobutyryl-(S)-phenylalanyl-(R)-prolyl-(S)-2-aminosuberoyl-]

Base Information

• Chemical Name: cyclo[2-aminoisobutyryl-(S)-phenylalanyl-(R)-prolyl-(S)-2-aminosuberoyl-]
• CAS No.: 104849-05-0
• Molecular Formula: C₂₆H₃₆N₄O₆
• Molecular Weight: 500.595
• Mol file: 104849-05-0.mol

Synonyms:cyclo[2-aminoisobutyryl-(S)-phenylalanyl-(R)-prolyl-(S)-2-aminosuberoyl-]

Chemical Property of cyclo[2-aminoisobutyryl-(S)-phenylalanyl-(R)-prolyl-(S)-2-aminosuberoyl-]

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of cyclo[2-aminoisobutyryl-(S)-phenylalanyl-(R)-prolyl-(S)-2-aminosuberoyl-]

There total 26 articles about cyclo[2-aminoisobutyryl-(S)-phenylalanyl-(R)-prolyl-(S)-2-aminosuberoyl-] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(-)-benzyl 6-[(3S,9S,14aR)-9-benzyl-6,6-dimethyl-1,4,7,10-tetraoxotetradecahydropyrrolo[1,2-a][1,4,7,10]tetraazacyclododecin-3-yl]hexanoate (286436-68-8) → cyclo[2-aminoisobutyryl-(S)-phenylalanyl-(R)-prolyl-(S)-2-aminosuberoyl-] (104849-05-0)

Guidance literature:

With palladium on activated charcoal; hydrogen; In methanol; for 12h;

DOI:10.1007/s00726-011-0947-6

Reference yield: 90.0%

(5S,11S,13aR)-5-Benzyl-11-((R)-6,7-dihydroxy-octyl)-8,8-dimethyl-decahydro-3a,6,9,12-tetraaza-cyclopentacyclododecene-4,7,10,13-tetraone → cyclo[2-aminoisobutyryl-(S)-phenylalanyl-(R)-prolyl-(S)-2-aminosuberoyl-] (104849-05-0)

Guidance literature:

With ruthenium trichloride; sodium periodate; In water; acetonitrile; at 20 ℃; for 3h;

DOI:10.7164/antibiotics.53.793

Reference yield: 80.0%

C28H40N4O5 → cyclo[2-aminoisobutyryl-(S)-phenylalanyl-(R)-prolyl-(S)-2-aminosuberoyl-] (104849-05-0)

Guidance literature:

With acetic acid; bis-[(trifluoroacetoxy)iodo]benzene; at 20 ℃; for 0.5h;

DOI:10.1021/acs.orglett.9b03305

upstream raw materials:

cyclo

(-)-benzyl 6-[(3S,9S,14aR)-9-benzyl-6,6-dimethyl-1,4,7,10-tetraoxotetradecahydropyrrolo[1,2-a][1,4,7,10]tetraazacyclododecin-3-yl]hexanoate

L-proline t-butyl ester

(+)-(R)-tert-butyl 1-[(S)-2-amino-3-phenylpropanoyl]pyrrolidine-2-carboxylate

Downstream raw materials:

(2S)-L-α-Aminosuberic acid

(5S,11S,13aR)-5-Benzyl-11-(7-diazo-6-oxo-heptyl)-8,8-dimethyl-decahydro-3a,6,9,12-tetraaza-cyclopentacyclododecene-4,7,10,13-tetraone

(-)-(3S,9S,14aR)-9-benzyl-3-(7-chloro-6-oxoheptyl)-6,6-dimethyldecahydropyrrolo[1,2-a][1,4,7,10]tetraazacyclododecine-1,4,7,10-tetraone