4-(2-((tert-butyldimethylsilyl)oxy)-2-(4,5,5-trimethyl-1-tosyl-1,5-dihydrobenzo[cd]indol-3-yl)ethyl)-5,5-dimethyl-1-tosyl-1,5-dihydrobenzo[cd]indole-3-carbaldehyde

Base Information

Chemical Name:4-(2-((tert-butyldimethylsilyl)oxy)-2-(4,5,5-trimethyl-1-tosyl-1,5-dihydrobenzo[cd]indol-3-yl)ethyl)-5,5-dimethyl-1-tosyl-1,5-dihydrobenzo[cd]indole-3-carbaldehyde
CAS No.:1335030-93-7
Molecular Formula:C₅₀H₅₆N₂O₆S₂Si
Molecular Weight:873.222
Hs Code.:

4-(2-((tert-butyldimethylsilyl)oxy)-2-(4,5,5-trimethyl-1-tosyl-1,5-dihydrobenzo[cd]indol-3-yl)ethyl)-5,5-dimethyl-1-tosyl-1,5-dihydrobenzo[cd]indole-3-carbaldehyde

Synonyms:4-(2-((tert-butyldimethylsilyl)oxy)-2-(4,5,5-trimethyl-1-tosyl-1,5-dihydrobenzo[cd]indol-3-yl)ethyl)-5,5-dimethyl-1-tosyl-1,5-dihydrobenzo[cd]indole-3-carbaldehyde

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Chemical Property of 4-(2-((tert-butyldimethylsilyl)oxy)-2-(4,5,5-trimethyl-1-tosyl-1,5-dihydrobenzo[cd]indol-3-yl)ethyl)-5,5-dimethyl-1-tosyl-1,5-dihydrobenzo[cd]indole-3-carbaldehyde

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Technology Process of 4-(2-((tert-butyldimethylsilyl)oxy)-2-(4,5,5-trimethyl-1-tosyl-1,5-dihydrobenzo[cd]indol-3-yl)ethyl)-5,5-dimethyl-1-tosyl-1,5-dihydrobenzo[cd]indole-3-carbaldehyde

There total 8 articles about 4-(2-((tert-butyldimethylsilyl)oxy)-2-(4,5,5-trimethyl-1-tosyl-1,5-dihydrobenzo[cd]indol-3-yl)ethyl)-5,5-dimethyl-1-tosyl-1,5-dihydrobenzo[cd]indole-3-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 49784-50-1
(E)-4-chloro-3-methyl-but-3-en-2-one

: 1335030-90-4
(Z)-3-(((tert-butyldimethylsilyl)oxy)methylene)-5,5-dimethyl-4-methylene-1-tosyl-1,3,4,5-tetrahydrobenzo[cd]indole

: 1335030-88-0
4,5,5-trimethyl-1-tosyl-1,5-dihydrobenzo[cd]indole-3-carbaldehyde

: rac-1-((8R,9S,10R)-10-((tert-butyldimethylsilyl)oxy)-8-chloro-6,6,9-trimethyl-2-tosyl-2,6,7,8,9,10-hexahydronaphtho[1,2,3-cd]indol-9-yl)ethanone

: 1335030-93-7
4-(2-((tert-butyldimethylsilyl)oxy)-2-(4,5,5-trimethyl-1-tosyl-1,5-dihydrobenzo[cd]indol-3-yl)ethyl)-5,5-dimethyl-1-tosyl-1,5-dihydrobenzo[cd]indole-3-carbaldehyde

Guidance literature:: With ethylaluminum dichloride; In dichloromethane; toluene; at -78 - -23 ℃; for 3h; diastereoselective reaction; Inert atmosphere;
DOI:10.1002/anie.201100957

Reference yield:

: 1335030-86-8
1-tosyl-4,5,5-trimethyl-4,5-dihydrobenzo[cd]indol-3(1H)-one

: rac-1-((8R,9S,10R)-10-((tert-butyldimethylsilyl)oxy)-8-chloro-6,6,9-trimethyl-2-tosyl-2,6,7,8,9,10-hexahydronaphtho[1,2,3-cd]indol-9-yl)ethanone

: 1335030-93-7
4-(2-((tert-butyldimethylsilyl)oxy)-2-(4,5,5-trimethyl-1-tosyl-1,5-dihydrobenzo[cd]indol-3-yl)ethyl)-5,5-dimethyl-1-tosyl-1,5-dihydrobenzo[cd]indole-3-carbaldehyde

Guidance literature:: Multi-step reaction with 5 steps

1.1: 2,6-di-tert-butyl-4-methylpyridine / dichloromethane / 22 h / 0 - 20 °C / Inert atmosphere

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 4 h / 100 °C / Inert atmosphere

3.1: diisobutylaluminium hydride / toluene / 1 h / 0 °C / Inert atmosphere

3.2: 6 h / 0 - 20 °C / Inert atmosphere

4.1: triethylamine / dichloromethane / 10 h / -10 °C / Inert atmosphere

5.1: titanium tetrachloride / dichloromethane / 0.5 h / -20 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2,6-di-tert-butyl-4-methylpyridine; titanium tetrachloride; diisobutylaluminium hydride; triethylamine; In dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1002/anie.201100957

Reference yield:

: 1335031-03-2
4,5,5-trimethyl-1-tosyl-1,5-dihydrobenzo[cd]indol-3-yl trifluoromethanesulfonate

: rac-1-((8R,9S,10R)-10-((tert-butyldimethylsilyl)oxy)-8-chloro-6,6,9-trimethyl-2-tosyl-2,6,7,8,9,10-hexahydronaphtho[1,2,3-cd]indol-9-yl)ethanone

: 1335030-93-7
4-(2-((tert-butyldimethylsilyl)oxy)-2-(4,5,5-trimethyl-1-tosyl-1,5-dihydrobenzo[cd]indol-3-yl)ethyl)-5,5-dimethyl-1-tosyl-1,5-dihydrobenzo[cd]indole-3-carbaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 4 h / 100 °C / Inert atmosphere

2.1: diisobutylaluminium hydride / toluene / 1 h / 0 °C / Inert atmosphere

2.2: 6 h / 0 - 20 °C / Inert atmosphere

3.1: triethylamine / dichloromethane / 10 h / -10 °C / Inert atmosphere

4.1: titanium tetrachloride / dichloromethane / 0.5 h / -20 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; titanium tetrachloride; diisobutylaluminium hydride; triethylamine; In dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1002/anie.201100957