(2S,3S)-3-Hydroxy-2,5-dimethyl-hexanethioic acid S-{(1S,2R)-2-[benzyl-(2,4,6-trimethyl-benzenesulfonyl)-amino]-1-phenyl-propyl} ester

Base Information

Chemical Name:(2S,3S)-3-Hydroxy-2,5-dimethyl-hexanethioic acid S-{(1S,2R)-2-[benzyl-(2,4,6-trimethyl-benzenesulfonyl)-amino]-1-phenyl-propyl} ester
CAS No.:913288-82-1
Molecular Formula:C₃₃H₄₃NO₄S₂
Molecular Weight:581.841
Hs Code.:

Synonyms:(2S,3S)-3-Hydroxy-2,5-dimethyl-hexanethioic acid S-{(1S,2R)-2-[benzyl-(2,4,6-trimethyl-benzenesulfonyl)-amino]-1-phenyl-propyl} ester

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Chemical Property of (2S,3S)-3-Hydroxy-2,5-dimethyl-hexanethioic acid S-{(1S,2R)-2-[benzyl-(2,4,6-trimethyl-benzenesulfonyl)-amino]-1-phenyl-propyl} ester

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Technology Process of (2S,3S)-3-Hydroxy-2,5-dimethyl-hexanethioic acid S-{(1S,2R)-2-[benzyl-(2,4,6-trimethyl-benzenesulfonyl)-amino]-1-phenyl-propyl} ester

There total 9 articles about (2S,3S)-3-Hydroxy-2,5-dimethyl-hexanethioic acid S-{(1S,2R)-2-[benzyl-(2,4,6-trimethyl-benzenesulfonyl)-amino]-1-phenyl-propyl} ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 913288-78-5
(1'S,2'R)-2'-(N-benzyl-N-mesitylenesulfonylamino)-1'-phenylpropyl thiolpropionate

: 590-86-3
isovaleraldehyde

: 3-Hydroxy-2,5-dimethyl-hexanethioic acid S-{(1S,2R)-2-[benzyl-(2,4,6-trimethyl-benzenesulfonyl)-amino]-1-phenyl-propyl} ester

: 913288-82-1
(2S,3S)-3-Hydroxy-2,5-dimethyl-hexanethioic acid S-{(1S,2R)-2-[benzyl-(2,4,6-trimethyl-benzenesulfonyl)-amino]-1-phenyl-propyl} ester

Guidance literature:: With triethylamine; dicyclohexyl(((trifluoromethyl)sulfonyl)oxy)borane; In hexane; dichloromethane; at -78 - 0 ℃; for 3h;
DOI:10.1021/ol0614774

Reference yield:

: 37577-28-9,58550-13-3,757124-50-8
(1S,2R)-(+)-norphedrine

: 913288-82-1
(2S,3S)-3-Hydroxy-2,5-dimethyl-hexanethioic acid S-{(1S,2R)-2-[benzyl-(2,4,6-trimethyl-benzenesulfonyl)-amino]-1-phenyl-propyl} ester

Guidance literature:: Multi-step reaction with 7 steps

1: 95 percent / Et₃N / CH₂Cl₂ / 2 h / 0 °C

2: 87 percent / methanesulfonylchloride; Et₃N / 14.17 h / 0 - 20 °C

3: 93 percent / PBu₃ / acetonitrile; H₂O / 18 h / 20 °C

4: NaH / dimethylformamide / 18 h / 20 °C

5: 96 percent / NaOMe / methanol / 1.5 h / 20 °C

6: 83 percent / pyridine / CH₂Cl₂ / 18 h / 0 - 20 °C

7: 94 percent / dicyclohexylboron triflate; Et₃N / CH₂Cl₂; hexane / 3 h / -78 - 0 °C

With pyridine; tributylphosphine; sodium methylate; sodium hydride; methanesulfonyl chloride; triethylamine; dicyclohexyl(((trifluoromethyl)sulfonyl)oxy)borane; In methanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ol0614774

Reference yield:

: 773-64-8
2-mesitylenesulphonyl chloride

: 913288-82-1
(2S,3S)-3-Hydroxy-2,5-dimethyl-hexanethioic acid S-{(1S,2R)-2-[benzyl-(2,4,6-trimethyl-benzenesulfonyl)-amino]-1-phenyl-propyl} ester

Guidance literature:: Multi-step reaction with 7 steps

1: 95 percent / Et₃N / CH₂Cl₂ / 2 h / 0 °C

2: 87 percent / methanesulfonylchloride; Et₃N / 14.17 h / 0 - 20 °C

3: 93 percent / PBu₃ / acetonitrile; H₂O / 18 h / 20 °C

4: NaH / dimethylformamide / 18 h / 20 °C

5: 96 percent / NaOMe / methanol / 1.5 h / 20 °C

6: 83 percent / pyridine / CH₂Cl₂ / 18 h / 0 - 20 °C

7: 94 percent / dicyclohexylboron triflate; Et₃N / CH₂Cl₂; hexane / 3 h / -78 - 0 °C

With pyridine; tributylphosphine; sodium methylate; sodium hydride; methanesulfonyl chloride; triethylamine; dicyclohexyl(((trifluoromethyl)sulfonyl)oxy)borane; In methanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ol0614774