N-^α-(tert-butyloxycarbonyl)-N-^ε-10-methylpteroyl)-L-γ-glutamyl>-L-lysine tert-butyl(α-Glu) ester

Base Information

• Chemical Name: N-^α-(tert-butyloxycarbonyl)-N-^ε-10-methylpteroyl)-L-γ-glutamyl>-L-lysine tert-butyl(α-Glu) ester
• CAS No.: 89637-95-6
• Molecular Formula: C₃₅H₅₀N₁₀O₈
• Molecular Weight: 738.844

Synonyms:N-^α-(tert-butyloxycarbonyl)-N-^ε-10-methylpteroyl)-L-γ-glutamyl>-L-lysine tert-butyl(α-Glu) ester

Chemical Property of N-^α-(tert-butyloxycarbonyl)-N-^ε-10-methylpteroyl)-L-γ-glutamyl>-L-lysine tert-butyl(α-Glu) ester

Chemical Property:

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Technology Process of N-^α-(tert-butyloxycarbonyl)-N-^ε-10-methylpteroyl)-L-γ-glutamyl>-L-lysine tert-butyl(α-Glu) ester

There total 3 articles about N-^α-(tert-butyloxycarbonyl)-N-^ε-10-methylpteroyl)-L-γ-glutamyl>-L-lysine tert-butyl(α-Glu) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

N-α-(tert-butyloxycarbonyl)-N-ε-10-methylpteroyl)-L-γ-glutamyl>-L-lysine tert-butyl(α-Glu)methyl(Lys) ester (89637-90-1) → N-α-(tert-butyloxycarbonyl)-N-ε-10-methylpteroyl)-L-γ-glutamyl>-L-lysine tert-butyl(α-Glu) ester (89637-95-6)

Guidance literature:

With barium dihydroxide; In ethanol; water; Ambient temperature;

DOI:10.1021/jm00373a014

Reference yield:

(S)-5-(tert-butoxy)-4-(4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)-5-oxopentanoic acid (79640-70-3) → N-α-(tert-butyloxycarbonyl)-N-ε-10-methylpteroyl)-L-γ-glutamyl>-L-lysine tert-butyl(α-Glu) ester (89637-95-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 76 percent / diethyl phosphorocyanidate, Et₃N / dimethylformamide / 0 - 20 °C

2: 87 percent / Ba(OH)2*8H₂O / ethanol; H₂O / Ambient temperature

With barium dihydroxide; diethyl cyanophosphonate; triethylamine; In ethanol; water; N,N-dimethyl-formamide;

DOI:10.1021/jm00373a014

Reference yield:

N,2-[(1,1-dimethylethoxy)carbonyl]-L-lysine methyl ester hydrochloride (99532-86-2) → N-α-(tert-butyloxycarbonyl)-N-ε-10-methylpteroyl)-L-γ-glutamyl>-L-lysine tert-butyl(α-Glu) ester (89637-95-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 76 percent / diethyl phosphorocyanidate, Et₃N / dimethylformamide / 0 - 20 °C

2: 87 percent / Ba(OH)2*8H₂O / ethanol; H₂O / Ambient temperature

With barium dihydroxide; diethyl cyanophosphonate; triethylamine; In ethanol; water; N,N-dimethyl-formamide;

DOI:10.1021/jm00373a014

upstream raw materials:

N-^α-(tert-butyloxycarbonyl)-N-^ε-10-methylpteroyl)-L-γ-glutamyl>-L-lysine tert-butyl(α-Glu)methyl(Lys) ester

(S)-5-(tert-butoxy)-4-(4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)-5-oxopentanoic acid

N,2-[(1,1-dimethylethoxy)carbonyl]-L-lysine methyl ester hydrochloride

Downstream raw materials:

N-^ε-10-methylpteroyl)-L-γ-glutamyl>-L-lysine

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