(S)-3-(1-(2-amino-5-(methylsulfonyl)pyrimidin-4-ylamino)ethyl)-8-chloro-2-phenylisoquinolin-1(2H)-one

Base Information

Chemical Name:(S)-3-(1-(2-amino-5-(methylsulfonyl)pyrimidin-4-ylamino)ethyl)-8-chloro-2-phenylisoquinolin-1(2H)-one
CAS No.:1425042-40-5
Molecular Formula:C₂₂H₂₀ClN₅O₃S
Molecular Weight:469.952
Hs Code.:

Synonyms:(S)-3-(1-(2-amino-5-(methylsulfonyl)pyrimidin-4-ylamino)ethyl)-8-chloro-2-phenylisoquinolin-1(2H)-one

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Chemical Property of (S)-3-(1-(2-amino-5-(methylsulfonyl)pyrimidin-4-ylamino)ethyl)-8-chloro-2-phenylisoquinolin-1(2H)-one

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Technology Process of (S)-3-(1-(2-amino-5-(methylsulfonyl)pyrimidin-4-ylamino)ethyl)-8-chloro-2-phenylisoquinolin-1(2H)-one

There total 6 articles about (S)-3-(1-(2-amino-5-(methylsulfonyl)pyrimidin-4-ylamino)ethyl)-8-chloro-2-phenylisoquinolin-1(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1425044-63-8
C₂₂H₂₀ClN₅OS

: 1425042-40-5
(S)-3-(1-(2-amino-5-(methylsulfonyl)pyrimidin-4-ylamino)ethyl)-8-chloro-2-phenylisoquinolin-1(2H)-one

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 0.5h;

Reference yield:

: 1386861-46-6
2-chloro-6-methyl-N-phenylbenzamide

: 1425042-40-5
(S)-3-(1-(2-amino-5-(methylsulfonyl)pyrimidin-4-ylamino)ethyl)-8-chloro-2-phenylisoquinolin-1(2H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -30 - -10 °C / Inert atmosphere

1.2: 2 h / -30 - -10 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 16 h / 120 °C / Sealed tube

3.1: sodium carbonate; copper(l) iodide / isopropyl alcohol / 24 h / 80 °C / Sealed tube

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.5 h / 20 °C

With copper(l) iodide; n-butyllithium; sodium carbonate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; hexane; dichloromethane; isopropyl alcohol;

Reference yield:

: 62-53-3
aniline

: 1425042-40-5
(S)-3-(1-(2-amino-5-(methylsulfonyl)pyrimidin-4-ylamino)ethyl)-8-chloro-2-phenylisoquinolin-1(2H)-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C

1.2: 2 h / 20 - 40 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -30 - -10 °C / Inert atmosphere

2.2: 2 h / -30 - -10 °C / Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 16 h / 120 °C / Sealed tube

4.1: sodium carbonate; copper(l) iodide / isopropyl alcohol / 24 h / 80 °C / Sealed tube

5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.5 h / 20 °C

With copper(l) iodide; n-butyllithium; oxalyl dichloride; sodium carbonate; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; hexane; dichloromethane; isopropyl alcohol;