3-(Benzylamino)-4-hydroxy-1-cyclohexen-1,4-dicarbonsaeure-dimethylester

Base Information

• Chemical Name: 3-(Benzylamino)-4-hydroxy-1-cyclohexen-1,4-dicarbonsaeure-dimethylester
• CAS No.: 85111-31-5
• Molecular Formula: C₁₇H₂₁NO₅
• Molecular Weight: 319.357
• Mol file: 85111-31-5.mol

Synonyms:3-(Benzylamino)-4-hydroxy-1-cyclohexen-1,4-dicarbonsaeure-dimethylester

Chemical Property of 3-(Benzylamino)-4-hydroxy-1-cyclohexen-1,4-dicarbonsaeure-dimethylester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(Benzylamino)-4-hydroxy-1-cyclohexen-1,4-dicarbonsaeure-dimethylester

There total 1 articles about 3-(Benzylamino)-4-hydroxy-1-cyclohexen-1,4-dicarbonsaeure-dimethylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

7-Oxabicyclo<4.1.0>hept-4-en-1,4-dicarbonsaeure-dimethylester (61846-10-4) + benzylamine (100-46-9) → 3-(Benzylamino)-4-hydroxy-1-cyclohexen-1,4-dicarbonsaeure-dimethylester (85111-31-5)

Guidance literature:

With phosphoric acid; In benzene; for 16h; Heating;

Reference yield: 60.0%

3-(Benzylamino)-4-hydroxy-1-cyclohexen-1,4-dicarbonsaeure-dimethylester (85111-31-5) → 7-Benzyl-7-azabicyclo<4.1.0>hept-4-en-1,4-dicarbonsaeure-dimethylester (66124-90-1)

Guidance literature:

With triethylamine; triphenylphosphine; In tetrachloromethane; acetonitrile; at 0 ℃; for 16h;

Reference yield:

3-(Benzylamino)-4-hydroxy-1-cyclohexen-1,4-dicarbonsaeure-dimethylester (85111-31-5) → 9-Benzyl-9-azabicyclo<4.2.1>nona-4,7-dien-1,4,7,8-tetracarbonsaeure-tetramethylester (85111-42-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 60 percent / Ph₃P, NEt₃ / CCl₄; acetonitrile / 16 h / 0 °C

2: 79 percent / C₆H₅Br / 3 h / 100 °C

With bromobenzene; triethylamine; triphenylphosphine; In tetrachloromethane; acetonitrile;

upstream raw materials:

7-Oxabicyclo<4.1.0>hept-4-en-1,4-dicarbonsaeure-dimethylester

benzylamine

Downstream raw materials:

7-Benzyl-7-azabicyclo<4.1.0>hept-4-en-1,4-dicarbonsaeure-dimethylester

9-Benzyl-9-azabicyclo<4.2.1>nona-4,7-dien-1,4,7,8-tetracarbonsaeure-tetramethylester