diethyl [2-({2-[4-(benzyloxy)-5H-pyrrolo[3,2-d]pyrimidin-7-yl]ethyl}amino)ethyl]phosphonate

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Chemical Name:diethyl [2-({2-[4-(benzyloxy)-5H-pyrrolo[3,2-d]pyrimidin-7-yl]ethyl}amino)ethyl]phosphonate
CAS No.:1404216-13-2
Molecular Formula:C₂₁H₂₉N₄O₄P
Molecular Weight:432.459
Hs Code.:

Synonyms:diethyl [2-({2-[4-(benzyloxy)-5H-pyrrolo[3,2-d]pyrimidin-7-yl]ethyl}amino)ethyl]phosphonate

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Chemical Property of diethyl [2-({2-[4-(benzyloxy)-5H-pyrrolo[3,2-d]pyrimidin-7-yl]ethyl}amino)ethyl]phosphonate

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Technology Process of diethyl [2-({2-[4-(benzyloxy)-5H-pyrrolo[3,2-d]pyrimidin-7-yl]ethyl}amino)ethyl]phosphonate

There total 6 articles about diethyl [2-({2-[4-(benzyloxy)-5H-pyrrolo[3,2-d]pyrimidin-7-yl]ethyl}amino)ethyl]phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1606-75-3
(2-oxoethyl)phosphonic acid diethyl ester

: 1404216-10-9
2-[4-(benzyloxy)-5H-pyrrolo[3,2-d]pyrimidin-7-yl]ethane-1-amine

: 1404216-13-2
diethyl [2-({2-[4-(benzyloxy)-5H-pyrrolo[3,2-d]pyrimidin-7-yl]ethyl}amino)ethyl]phosphonate

Guidance literature:: (2-oxoethyl)phosphonic acid diethyl ester; 2-[4-(benzyloxy)-5H-pyrrolo[3,2-d]pyrimidin-7-yl]ethane-1-amine; In ethanol; at 70 ℃; for 0.5h;

With sodium tetrahydroborate; ethanol; at 20 ℃; for 0.5h;

Reference yield:

: 1166948-78-2
4-(benzyloxy)-5H-pyrrolo[3,2-d]pyrimidine

: 1404216-13-2
diethyl [2-({2-[4-(benzyloxy)-5H-pyrrolo[3,2-d]pyrimidin-7-yl]ethyl}amino)ethyl]phosphonate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium acetate / 1,4-dioxane; water / 4 h / 95 °C

2.1: tetrahydrofuran / 18 h / 20 °C

3.1: sodium methylate / methanol / 0.17 h / Inert atmosphere

3.2: 2 h

3.3: pH 3

4.1: sodium tetrahydroborate; methanol / cobalt(II) chloride hexahydrate / 0.5 h / 0 °C

5.1: ethanol / 0.5 h / 70 °C

5.2: 0.5 h / 20 °C

With methanol; sodium tetrahydroborate; sodium methylate; sodium acetate; cobalt(II) chloride hexahydrate; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water;

Reference yield:

: 1404216-07-4
{[4-(benzyloxy)-5H-pyrrolo[3,2-d]pyrimidin-7-yl]methyl}dimethylamine

: 1404216-13-2
diethyl [2-({2-[4-(benzyloxy)-5H-pyrrolo[3,2-d]pyrimidin-7-yl]ethyl}amino)ethyl]phosphonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrahydrofuran / 18 h / 20 °C

2.1: sodium methylate / methanol / 0.17 h / Inert atmosphere

2.2: 2 h

2.3: pH 3

3.1: sodium tetrahydroborate; methanol / cobalt(II) chloride hexahydrate / 0.5 h / 0 °C

4.1: ethanol / 0.5 h / 70 °C

4.2: 0.5 h / 20 °C

With methanol; sodium tetrahydroborate; sodium methylate; cobalt(II) chloride hexahydrate; In tetrahydrofuran; methanol; ethanol;