4-methyl-2-{6-chloro-2-[4-(4-trifluoromethoxyphenyl)-imidazol-1-yl]-pyrimidin-4-ylamino}-pentanoic acid (3-ethoxypropyl)amide

Base Information

• Chemical Name: 4-methyl-2-{6-chloro-2-[4-(4-trifluoromethoxyphenyl)-imidazol-1-yl]-pyrimidin-4-ylamino}-pentanoic acid (3-ethoxypropyl)amide
• CAS No.: 684221-38-3
• Molecular Formula: C₂₅H₃₀ClF₃N₆O₃
• Molecular Weight: 555

Synonyms:4-methyl-2-{6-chloro-2-[4-(4-trifluoromethoxyphenyl)-imidazol-1-yl]-pyrimidin-4-ylamino}-pentanoic acid (3-ethoxypropyl)amide

Chemical Property of 4-methyl-2-{6-chloro-2-[4-(4-trifluoromethoxyphenyl)-imidazol-1-yl]-pyrimidin-4-ylamino}-pentanoic acid (3-ethoxypropyl)amide

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Technology Process of 4-methyl-2-{6-chloro-2-[4-(4-trifluoromethoxyphenyl)-imidazol-1-yl]-pyrimidin-4-ylamino}-pentanoic acid (3-ethoxypropyl)amide

There total 1 articles about 4-methyl-2-{6-chloro-2-[4-(4-trifluoromethoxyphenyl)-imidazol-1-yl]-pyrimidin-4-ylamino}-pentanoic acid (3-ethoxypropyl)amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(4-trifluoromethoxyphenyl)imidazole (684221-40-7) + 2-(2,6-dichloropyrimidin-4-ylamino)-4-methylpentanoic acid (3-ethoxypropyl)amide (684221-37-2) → 4-methyl-2-{6-chloro-2-[4-(4-trifluoromethoxyphenyl)-imidazol-1-yl]-pyrimidin-4-ylamino}-pentanoic acid (3-ethoxypropyl)amide (684221-38-3)

Guidance literature:

With potassium fluoride; potassium carbonate; In dimethyl sulfoxide; at 100 ℃; for 17h;

Reference yield:

4-methyl-2-{6-chloro-2-[4-(4-trifluoromethoxyphenyl)-imidazol-1-yl]-pyrimidin-4-ylamino}-pentanoic acid (3-ethoxypropyl)amide (684221-38-3) + 4,4,4-trifluorobutanol (461-18-7) → 4-methyl-2-{6-(4,4,4-trifluorobutoxy)-2-[4-(4-trifluoromethoxyphenyl)-imidazol-1-yl]pyrimidin-4-ylamino}pentanoic acid (3-ethoxypropyl)amide (684221-41-8)

Guidance literature:

With sodium hydride; In dimethyl sulfoxide; at 20 ℃; for 17h;

Reference yield:

4-methyl-2-{6-chloro-2-[4-(4-trifluoromethoxyphenyl)-imidazol-1-yl]-pyrimidin-4-ylamino}-pentanoic acid (3-ethoxypropyl)amide (684221-38-3) + 3,3,3-Trifluoropropanol (2240-88-2) → 4-methyl-2-{6-(3,3,3-trifluoropropoxy)-2-[4-(4-trifluoromethoxyphenyl) imidazol-1-yl] pyrimidin-4-ylamino} pentanoic acid (3-ethoxypropyl)amide (684221-42-9)

Guidance literature:

With potassium fluoride; potassium carbonate; N-ethyl-N,N-diisopropylamine; at 80 ℃; for 17h;

upstream raw materials:

4-(4-trifluoromethoxyphenyl)imidazole

2-(2,6-dichloropyrimidin-4-ylamino)-4-methylpentanoic acid (3-ethoxypropyl)amide

Downstream raw materials:

4-methyl-2-{6-(3,3,3-trifluoropropoxy)-2-[4-(4-trifluoromethoxyphenyl) imidazol-1-yl] pyrimidin-4-ylamino} pentanoic acid (3-ethoxypropyl)amide

4-methyl-2-{6-(4,4,4-trifluorobutoxy)-2-[4-(4-trifluoromethoxyphenyl)-imidazol-1-yl]pyrimidin-4-ylamino}pentanoic acid (3-ethoxypropyl)amide

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