(S)-3-[(R)-2-(Adamantan-2-yloxycarbonylamino)-3-(1H-indol-3-yl)-2-methyl-propionylamino]-4-(4-iodo-phenyl)-butyric acid 2-trimethylsilanyl-ethyl ester

Base Information

• Chemical Name: (S)-3-[(R)-2-(Adamantan-2-yloxycarbonylamino)-3-(1H-indol-3-yl)-2-methyl-propionylamino]-4-(4-iodo-phenyl)-butyric acid 2-trimethylsilanyl-ethyl ester
• CAS No.: 159630-57-6
• Molecular Formula: C₃₈H₅₀IN₃O₅Si
• Molecular Weight: 783.822

Synonyms:(S)-3-[(R)-2-(Adamantan-2-yloxycarbonylamino)-3-(1H-indol-3-yl)-2-methyl-propionylamino]-4-(4-iodo-phenyl)-butyric acid 2-trimethylsilanyl-ethyl ester

Chemical Property of (S)-3-[(R)-2-(Adamantan-2-yloxycarbonylamino)-3-(1H-indol-3-yl)-2-methyl-propionylamino]-4-(4-iodo-phenyl)-butyric acid 2-trimethylsilanyl-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-3-[(R)-2-(Adamantan-2-yloxycarbonylamino)-3-(1H-indol-3-yl)-2-methyl-propionylamino]-4-(4-iodo-phenyl)-butyric acid 2-trimethylsilanyl-ethyl ester

There total 6 articles about (S)-3-[(R)-2-(Adamantan-2-yloxycarbonylamino)-3-(1H-indol-3-yl)-2-methyl-propionylamino]-4-(4-iodo-phenyl)-butyric acid 2-trimethylsilanyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-Boc-4-I-Phe-OH (103882-09-3,62129-44-6) → (S)-3-[(R)-2-(Adamantan-2-yloxycarbonylamino)-3-(1H-indol-3-yl)-2-methyl-propionylamino]-4-(4-iodo-phenyl)-butyric acid 2-trimethylsilanyl-ethyl ester (159630-57-6)

Guidance literature:

Multi-step reaction with 5 steps

1: N-methyl morpholine / tetrahydrofuran

2: diethyl ether / 0 - 20 °C

3: silver benzoate, Et₃N

4: p-toluenesulfonic acid / CH₂Cl₂ / Ambient temperature

5: 1.) 1-hydroxybenzotriazole, 1,3-dicyclohexylcarbodiimide / 1.) EtOAc, RT, 2.) EtOAc, RT

With 4-methyl-morpholine; silver benzoate; benzotriazol-1-ol; toluene-4-sulfonic acid; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; diethyl ether; dichloromethane;

DOI:10.1016/0968-0896(96)00185-X

Reference yield:

4-iodo-L-phenylalanine (1991-81-7,14173-41-2,24250-85-9,62561-75-5) → (S)-3-[(R)-2-(Adamantan-2-yloxycarbonylamino)-3-(1H-indol-3-yl)-2-methyl-propionylamino]-4-(4-iodo-phenyl)-butyric acid 2-trimethylsilanyl-ethyl ester (159630-57-6)

Guidance literature:

Multi-step reaction with 6 steps

1: aq. NaOH, NaHCO₃ / dioxane / 0 - 20 °C

2: N-methyl morpholine / tetrahydrofuran

3: diethyl ether / 0 - 20 °C

4: silver benzoate, Et₃N

5: p-toluenesulfonic acid / CH₂Cl₂ / Ambient temperature

6: 1.) 1-hydroxybenzotriazole, 1,3-dicyclohexylcarbodiimide / 1.) EtOAc, RT, 2.) EtOAc, RT

With 4-methyl-morpholine; sodium hydroxide; silver benzoate; sodium hydrogencarbonate; benzotriazol-1-ol; toluene-4-sulfonic acid; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; 1,4-dioxane; diethyl ether; dichloromethane;

DOI:10.1016/0968-0896(96)00185-X

Reference yield:

[(S)-3-Diazo-1-(4-iodo-benzyl)-2-oxo-propyl]-carbamic acid tert-butyl ester (134557-88-3) → (S)-3-[(R)-2-(Adamantan-2-yloxycarbonylamino)-3-(1H-indol-3-yl)-2-methyl-propionylamino]-4-(4-iodo-phenyl)-butyric acid 2-trimethylsilanyl-ethyl ester (159630-57-6)

Guidance literature:

Multi-step reaction with 3 steps

1: silver benzoate, Et₃N

2: p-toluenesulfonic acid / CH₂Cl₂ / Ambient temperature

3: 1.) 1-hydroxybenzotriazole, 1,3-dicyclohexylcarbodiimide / 1.) EtOAc, RT, 2.) EtOAc, RT

With silver benzoate; benzotriazol-1-ol; toluene-4-sulfonic acid; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane;

DOI:10.1016/0968-0896(96)00185-X

upstream raw materials:

N-[(2-adamantyloxy)-carbonyl]-α-methyl-R-tryptophane

(S)-3-Amino-4-(4-iodo-phenyl)-butyric acid 2-trimethylsilanyl-ethyl ester

4-iodo-L-phenylalanine

N-Boc-4-I-Phe-OH

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 159630-57-6 (S)-3-[(R)-2-(Adamantan-2-yloxycarbonylamino)-3-(1H-indol-3-yl)-2-methyl-propionylamino]-4-(4-iodo-phenyl)-butyric acid 2-trimethylsilanyl-ethyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send