Technology Process of 5-(3,7,11,15-tetramethyleicosyl)sulfonyl-1-phenyl-1H-tetrazole
There total 10 articles about 5-(3,7,11,15-tetramethyleicosyl)sulfonyl-1-phenyl-1H-tetrazole which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
3-chloro-benzenecarboperoxoic acid;
In
dichloromethane;
at 0 - 20 ℃;
DOI:10.1021/ja0123958
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: KHMDS / toluene; tetrahydrofuran / 0.83 h / -78 - 20 °C
1.2: 76 percent / tetrahydrofuran; toluene / -78 - 20 °C
2.1: 96 percent / Na; MeOH / 2 h
3.1: 98 percent / H2; NaHCO3 / PtO2 / tetrahydrofuran / 20 h / 2585.81 Torr
4.1: 93 percent / Ph3P; DIAD / tetrahydrofuran / 0.08 h
5.1: 98 percent / MCPBA / CH2Cl2 / 0 - 20 °C
6.1: LHMDS / tetrahydrofuran / 0.5 h / -78 °C
6.2: 90 percent / tetrahydrofuran / -78 - 20 °C
7.1: Na; MeOH / 2 h
8.1: 97 percent / H2; NaHCO3 / PtO2 / tetrahydrofuran / 2585.81 Torr
9.1: 92 percent / Ph3P; DIAD / tetrahydrofuran
10.1: 91 percent / MCPBA / CH2Cl2 / 0 - 20 °C
With
methanol; di-isopropyl azodicarboxylate; hydrogen; sodium; potassium hexamethylsilazane; sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; lithium hexamethyldisilazane;
platinum(IV) oxide;
In
tetrahydrofuran; dichloromethane; toluene;
1.1: Wittig olefination / 1.2: Wittig olefination / 4.1: Mitsunobu reaction / 9.1: Mitsunobu reaction;
DOI:10.1021/ja0123958
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: 98 percent / H2; NaHCO3 / PtO2 / tetrahydrofuran / 20 h / 2585.81 Torr
2.1: 93 percent / Ph3P; DIAD / tetrahydrofuran / 0.08 h
3.1: 98 percent / MCPBA / CH2Cl2 / 0 - 20 °C
4.1: LHMDS / tetrahydrofuran / 0.5 h / -78 °C
4.2: 90 percent / tetrahydrofuran / -78 - 20 °C
5.1: Na; MeOH / 2 h
6.1: 97 percent / H2; NaHCO3 / PtO2 / tetrahydrofuran / 2585.81 Torr
7.1: 92 percent / Ph3P; DIAD / tetrahydrofuran
8.1: 91 percent / MCPBA / CH2Cl2 / 0 - 20 °C
With
methanol; di-isopropyl azodicarboxylate; hydrogen; sodium; sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; lithium hexamethyldisilazane;
platinum(IV) oxide;
In
tetrahydrofuran; dichloromethane;
2.1: Mitsunobu reaction / 7.1: Mitsunobu reaction;
DOI:10.1021/ja0123958
