N-[2-amino-4-(hydroxymethyl)phenyl]-4-({[4-(pyridin-3-yl)pyrimidin-2-yl]amino}methyl)benzamide

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Chemical Name:N-[2-amino-4-(hydroxymethyl)phenyl]-4-({[4-(pyridin-3-yl)pyrimidin-2-yl]amino}methyl)benzamide
CAS No.:1448350-13-7
Molecular Formula:C₂₄H₂₂N₆O₂
Molecular Weight:426.478
Hs Code.:

Synonyms:N-[2-amino-4-(hydroxymethyl)phenyl]-4-({[4-(pyridin-3-yl)pyrimidin-2-yl]amino}methyl)benzamide

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Chemical Property of N-[2-amino-4-(hydroxymethyl)phenyl]-4-({[4-(pyridin-3-yl)pyrimidin-2-yl]amino}methyl)benzamide

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Technology Process of N-[2-amino-4-(hydroxymethyl)phenyl]-4-({[4-(pyridin-3-yl)pyrimidin-2-yl]amino}methyl)benzamide

There total 9 articles about N-[2-amino-4-(hydroxymethyl)phenyl]-4-({[4-(pyridin-3-yl)pyrimidin-2-yl]amino}methyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 1448350-19-3
N-(4-{[(tert-butyldimethylsilyl)oxy]methyl}-2-nitrophenyl)-4-({[4-(pyridin-3-yl)pyrimidin-2-yl]amino}methyl)benzamide

: 1448350-13-7
N-[2-amino-4-(hydroxymethyl)phenyl]-4-({[4-(pyridin-3-yl)pyrimidin-2-yl]amino}methyl)benzamide

Guidance literature:: With tin(II) chloride dihdyrate; ammonium acetate; In tetrahydrofuran; methanol; water; at 20 - 50 ℃; for 22h;
DOI:10.1021/jm400634n

Reference yield:

: 1588-83-6
4-amino-3-nitrobenzoic acid

: 1448350-13-7
N-[2-amino-4-(hydroxymethyl)phenyl]-4-({[4-(pyridin-3-yl)pyrimidin-2-yl]amino}methyl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: thionyl chloride / 16 h / Reflux

2: diisobutylaluminium hydride / dichloromethane; tetrahydrofuran / 0 - 20 °C

3: 1H-imidazole / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

4: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; pyridine; sodium hydride / mineral oil / 2.5 h / 20 °C / Inert atmosphere

5: tin(II) chloride dihdyrate; ammonium acetate / methanol; water; tetrahydrofuran / 22 h / 20 - 50 °C

With pyridine; 1H-imidazole; thionyl chloride; tin(II) chloride dihdyrate; ammonium acetate; sodium hydride; diisobutylaluminium hydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jm400634n

Reference yield:

: 3987-92-6
methyl 4-amino-3-nitrobenzoate

: 1448350-13-7
N-[2-amino-4-(hydroxymethyl)phenyl]-4-({[4-(pyridin-3-yl)pyrimidin-2-yl]amino}methyl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: diisobutylaluminium hydride / dichloromethane; tetrahydrofuran / 0 - 20 °C

2: 1H-imidazole / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

3: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; pyridine; sodium hydride / mineral oil / 2.5 h / 20 °C / Inert atmosphere

4: tin(II) chloride dihdyrate; ammonium acetate / methanol; water; tetrahydrofuran / 22 h / 20 - 50 °C

With pyridine; 1H-imidazole; tin(II) chloride dihdyrate; ammonium acetate; sodium hydride; diisobutylaluminium hydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jm400634n